Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Innovations in Care Delivery
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit New Manuscript
    • Submit Revised Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Innovations in Care Delivery
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit New Manuscript
    • Submit Revised Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

Share

July 12, 2022; 99 (2) Research Article

Association of Plaque Inflammation With Stroke Recurrence in Patients With Unproven Benefit From Carotid Revascularization

View ORCID ProfilePol Camps-Renom, John McCabe, View ORCID ProfileJoan Martí-Fàbregas, Nicola Giannotti, Alejandro Fernández-León, View ORCID ProfileJonathan P. McNulty, Jean-Claude Baron, Mary Barry, View ORCID ProfileShelagh B. Coutts, Simon Cronin, View ORCID ProfileRaquel Delgado-Mederos, Eamon Dolan, View ORCID ProfileShane Foley, View ORCID ProfileMarina Guasch-Jiménez, View ORCID ProfileDaniel Guisado-Alonso, Joseph A. Harbison, Gillian Horgan, View ORCID ProfileEoin C. Kavanagh, Michael Marnane, Alejandro Martínez-Domeño, Ciaran McDonnell, Vijay K. Sharma, View ORCID ProfileDavid Williams, Martin O. Connell, Sean Murphy, View ORCID ProfileLuis Prats-Sánchez, Peter J. Kelly
First published April 13, 2022, DOI: https://doi.org/10.1212/WNL.0000000000200525
Pol Camps-Renom
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Pol Camps-Renom
John McCabe
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joan Martí-Fàbregas
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Joan Martí-Fàbregas
Nicola Giannotti
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alejandro Fernández-León
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jonathan P. McNulty
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jonathan P. McNulty
Jean-Claude Baron
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mary Barry
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shelagh B. Coutts
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Shelagh B. Coutts
Simon Cronin
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Raquel Delgado-Mederos
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Raquel Delgado-Mederos
Eamon Dolan
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shane Foley
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Shane Foley
Marina Guasch-Jiménez
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Marina Guasch-Jiménez
Daniel Guisado-Alonso
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Daniel Guisado-Alonso
Joseph A. Harbison
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gillian Horgan
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eoin C. Kavanagh
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Eoin C. Kavanagh
Michael Marnane
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alejandro Martínez-Domeño
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ciaran McDonnell
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vijay K. Sharma
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Williams
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for David Williams
Martin O. Connell
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sean Murphy
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Luis Prats-Sánchez
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Luis Prats-Sánchez
Peter J. Kelly
From the Stroke Unit (P.C.-R., J.M.-F., R.D.-M., M.G.-J., D.G.-A., A.M.-D., L.P.-S.), Department of Neurology, Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Health Research Board Stroke Clinical Trials Network Ireland (J.M., S.C., E.D., J.A.H., G.H., M.M., S.M., P.J.K.); Neurovascular Clinical Science Unit (J.M., G.H., M.M., S.M., P.J.K.), Stroke Service and Department of Neurology, Mater University Hospital/University College Dublin; Radiography & Diagnostic Imaging (N.G., J.P.M., S.F.), School of Medicine, University College Dublin, Ireland; Discipline of Medical Imaging Science (N.G.), School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Australia; Department of Nuclear Medicine (A.F.-L.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Department of Neurology (J.-C.B.), Université de Paris, Hopital Sainte-Anne, France; Department of Vascular Surgery (M.B.), St. Vincent's University Hospital and University College Dublin, Ireland; Departments of Clinical Neurosciences, Radiology, and Community Health Sciences (S.B.C.), University of Calgary, Alberta, Canada; Department of Neurology (S.C.), Cork University Hospital; Department of Clinical Neuroscience (S.C.), College of Medicine and Health, University College Cork, Ireland; Connolly Hospital Dublin and Royal College of Surgeons (E.D.); Stroke Service, Department of Geriatric Medicine (J.A.H.), St. James' Hospital and Trinity College; Departments of Radiology (E.C.K., M.O.C.) and Vascular Surgery (C.M.), Mater University Hospital and University College Dublin, Ireland; Division of Neurology (V.K.S.), National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore; and Department of Geriatric and Stroke Medicine (D.W.), RCSI University of Medicine and Health Sciences/Beaumont Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Short Form
Citation
Association of Plaque Inflammation With Stroke Recurrence in Patients With Unproven Benefit From Carotid Revascularization
Pol Camps-Renom, John McCabe, Joan Martí-Fàbregas, Nicola Giannotti, Alejandro Fernández-León, Jonathan P. McNulty, Jean-Claude Baron, Mary Barry, Shelagh B. Coutts, Simon Cronin, Raquel Delgado-Mederos, Eamon Dolan, Shane Foley, Marina Guasch-Jiménez, Daniel Guisado-Alonso, Joseph A. Harbison, Gillian Horgan, Eoin C. Kavanagh, Michael Marnane, Alejandro Martínez-Domeño, Ciaran McDonnell, Vijay K. Sharma, David Williams, Martin O. Connell, Sean Murphy, Luis Prats-Sánchez, Peter J. Kelly
Neurology Jul 2022, 99 (2) e109-e118; DOI: 10.1212/WNL.0000000000200525

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
134

Share

  • Article
  • Figures & Data
  • Info & Disclosures
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Abstract

Background and Objectives In pooled analyses of endarterectomy trials for symptomatic carotid stenosis, several subgroups experienced no net benefit from revascularization. The validated symptomatic carotid atheroma inflammation lumen-stenosis (SCAIL) score includes stenosis severity and inflammation measured by PET and improves the identification of patients with recurrent stroke compared with lumen-stenosis alone. We investigated whether the SCAIL score improves the identification of recurrent stroke in subgroups with uncertain benefit from revascularization in endarterectomy trials.

Methods We did an individual-participant data pooled analysis of 3 prospective cohort studies (Dublin Carotid Atherosclerosis Study [DUCASS], 2008–2011; Biomarkers and Imaging of Vulnerable Atherosclerosis in Symptomatic Carotid Artery Disease [BIOVASC], 2014–2018; Barcelona Plaque Study, 2015–2018). Eligible patients had a recent nonsevere (modified Rankin Scale score ≤3) anterior circulation ischemic stroke/TIA and ipsilateral mild carotid stenosis (<50%); ipsilateral moderate carotid stenosis (50%–69%) plus at least 1 of female sex, age <65 years, diabetes mellitus, TIA, or delay >14 days to revascularization; or monocular loss of vision. Patients underwent coregistered carotid 18F-fluorodeoxyglucosePET/CT angiography (≤7 days from inclusion). The primary outcome was 90-day ipsilateral ischemic stroke. Multivariable Cox regression modeling was performed.

Results We included 135 patients. All patients started optimal modern-era medical treatment at admission, and 62 (45.9%) underwent carotid revascularization (36 within the first 14 days and 26 beyond). At 90 days, 18 (13.3%) patients had experienced at least 1 stroke recurrence. The risk of recurrence increased progressively according to the SCAIL score (0.0% in patients scoring 0–1, 15.1% scoring 2–3, and 26.7% scoring 4–5; p = 0.04). The adjusted (age, smoking, hypertension, diabetes, carotid revascularization, antiplatelets and statins) hazard ratio for ipsilateral recurrent stroke per 1-point SCAIL increase was 2.16 (95% CI 1.32–3.53; p = 0.002). A score ≥2 had a sensitivity of 100% for recurrence.

Discussion The SCAIL score improved the identification of early recurrent stroke in subgroups who did not experience benefit in endarterectomy trials. Randomized trials are needed to test whether a combined stenosis-inflammation strategy will improve selection for carotid revascularization when benefit is currently uncertain.

Classification of Evidence This study provides Class II evidence that, in patients with recent anterior circulation ischemic stroke who do not benefit from carotid revascularization, the SCAIL score accurately distinguishes those at risk for recurrent ipsilateral ischemic stroke.

Glossary

ARR=
absolute risk reduction;
BIOVASC=
Biomarkers and Imaging of Vulnerable Atherosclerosis in Symptomatic Carotid Artery Disease;
CEA=
carotid endarterectomy;
CTA=
CT angiography;
DUCASS=
Dublin Carotid Atherosclerosis Study;
ECST=
European Carotid Surgery Trial;
18F-FDG=
18F-fluorodeoxyglucose;
IQR=
interquartile range;
MRA=
magnetic resonance angiography;
NASCET=
North American Symptomatic Carotid Surgery Trial;
SCAIL=
symptomatic carotid atheroma inflammation lumen-stenosis;
SHS=
single hottest slice;
SUV=
standardized uptake value

Footnotes

  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Submitted and externally peer reviewed. The handling editor was Brad Worrall, MD, MSc, FAAN.

  • Class of Evidence: NPub.org/coe

  • Received August 24, 2021.
  • Accepted in final form March 1, 2022.
  • © 2022 American Academy of Neurology
View Full Text

AAN Members

We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.

Google Safari Microsoft Edge Firefox

Click here to login

AAN Non-Member Subscribers

Click here to login

Purchase access

For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)

Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here 

Purchase
Individual access to articles is available through the Add to Cart option on the article page.  Access for 1 day (from the computer you are currently using) is US$ 39.00.  Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means.  The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use.  Distributing copies (electronic or otherwise) of the article is not allowed.

Letters: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

If you are uploading a letter concerning an article:
You must have updated your disclosures within six months: http://submit.neurology.org

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Abstract
    • Glossary
    • Methods
    • Results
    • Discussion
    • Study Funding
    • Disclosure
    • Acknowledgment
    • Appendix Authors
    • Footnotes
    • References
  • Figures & Data
  • Info & Disclosures
Advertisement

Use of Whole-Genome Sequencing for Mitochondrial Disease Diagnosis

Dr. Robert Pitceathly and Dr. William Macken

► Watch

Related Articles

  • Spotlight on the July 12 Issue

Topics Discussed

  • All Cerebrovascular disease/Stroke
  • Class II
  • PET
  • Stroke prevention

Alert Me

  • Alert me when eletters are published
Neurology: 100 (12)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Education
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2023 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise