Notable in Neurology This Week
This issue features an article that investigates racial disparities in stroke recurrence; another reports on the long-term clinical outcomes of rituximab treatment in patients with neuromyelitis optica spectrum disorder and MOG antibody disease. A featured Contemporary Issues in Practice, Education, & Research discusses best practices of handling sensitive information regarding preclinical Alzheimer disease in the electronic health record.
Research Articles
APOE Alleles With Tau and Aβ Pathology in Patients With Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex in the Kii Peninsula
Researchers analyzed APOE polymorphisms in 18 autopsy patients with amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) in the Kii peninsula of Japan and revealed the relationship between APOE polymorphisms and tau pathology. Their findings suggested that the APOE ε2 allele is associated with increased tau pathology in patients with Kii ALS/PDC.
Page 978
Air Pollution Associated With Incident Stroke, Poststroke Cardiovascular Events, and Death: A Trajectory Analysis of a Prospective Cohort
Air pollution is a risk factor of stroke. This study reported that air pollution was associated with dynamic transitions from healthy state to stroke, poststroke cardiovascular events, and death, with a stronger effect for transition from health to stroke. Efforts to reduce exposures may be most beneficial to primary stroke prevention.
Page 982
Association of Time to Clinical Remission With Sustained Resolution in Children With New-Onset Infantile Spasms
This prospective, observational study followed children aged 2–24 months with new-onset infantile spasms treated with standard therapy. Treatment response occurred within 7 days for most patients with infantile spasms, suggesting that clinicians should reassess infantile spasms treatment at 1 week to determine whether additional treatment is necessary.
Page 984
Investigating Functional Network Abnormalities and Associations With Disability in Multiple Sclerosis
In this multicenter cross-sectional study, centrality analysis captured reconfiguration and topography changes of functional networks that were continuously occurring in multiple sclerosis. In this disease, centrality was reduced in sensorimotor and salience networks, and it increased in the default-mode network, with specific findings for phenotype and disability. Centrality may be a valuable marker for multiple sclerosis severity.
Page 986
NB: “A 23-Year-Old Woman Presenting With Cognitive Impairment and Gait Disturbance,” p. 997. To check out other Resident & Fellow Section Clinical Reasoning articles, point your browser to Neurology.org/N and click on the link to the Resident & Fellow Section. At the end of the issue, check out the Resident & Fellow Section Pearls & Oy-sters article discussing eastern equine encephalitis in an immunocompromised patient. This week also includes a Resident & Fellow Section Teaching NeuroImage titled “Primary Familial Brain Calcification in SLC20A2 Genotype.”
- Received September 27, 2022.
- Accepted in final form September 27, 2022.
- © 2022 American Academy of Neurology
Letters: Rapid online correspondence
REQUIREMENTS
If you are uploading a letter concerning an article:
You must have updated your disclosures within six months: http://submit.neurology.org
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Hemiplegic Migraine Associated With PRRT2 Variations A Clinical and Genetic Study
Dr. Robert Shapiro and Dr. Amynah Pradhan