Article Figures & Data
Figures
- Figure 1 Signal Loss and Asymmetry
123-I ioflupane SPECT in a healthy volunteer (A) and de novo Parkinson research participant (B) show characteristic left-right and anterior-posterior asymmetry seen in PD. This pattern of loss has bearing on the optimized uses of DaT imaging in clinical trials. DaT = dopamine transporter; PD = Parkinson disease.
- Figure 2 Baseline Regional Striatal SBR Analysis
Regional striatal subregion mean SBRs (green bars) demonstrate the topographic pattern consequent of the left-right and anterior-posterior differential asymmetry noted in Figure 1. SBR = specific binding ratio.
- Figure 3 Years to 100% Age-Expected SBR by Subregion
Estimate in years of duration of premotor pathologic progression for striatal subregions based on modeling of the exponential curve fit to Ioflupane SPECT SBRs determined a baseline, year 1, 2 and 4 scans. The most affected region, the contralateral putamen, suggests a nearly 13-year period of change where motor function remains intact. SBR = specific binding ratio.
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