Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
    • UDDA Revision Series
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
    • UDDA Revision Series
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

Share

August 03, 2018Article

White matter lesions

Spatial heterogeneity, links to risk factors, cognition, genetics, and atrophy

Mohamad Habes, Aristeidis Sotiras, Guray Erus, Jon B. Toledo, Deborah Janowitz, David A. Wolk, Haochang Shou, Nick R. Bryan, Jimit Doshi, Henry Völzke, Ulf Schminke, Wolfgang Hoffmann, Susan M. Resnick, Hans J. Grabe, Christos Davatzikos
First published August 3, 2018, DOI: https://doi.org/10.1212/WNL.0000000000006116
Mohamad Habes
From the Center for Biomedical Image Computing and Analytics (M.H., A.S., G.E., N.R.B., J.D., C.D.), Department of Neurology and Penn Memory Center (M.H., D.A.W.), and Department of Biostatistics and Epidemiology (H.S.), University of Pennsylvania, Philadelphia; Department of Psychiatry (M.H., D.J., H.J.G.), Institute for Community Medicine (M.H., H.V., W.H.), and Department of Neurology (U.S.), University of Greifswald, Germany; Department of Neurology (J.B.T.), Houston Methodist Hospital, TX; German Center for Neurodegenerative Diseases (W.H., H.J.G.), Rostock/Greifswald, Germany; and Laboratory of Behavioral Neuroscience (S.M.R.), National Institute on Aging, Baltimore, MD.
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Aristeidis Sotiras
From the Center for Biomedical Image Computing and Analytics (M.H., A.S., G.E., N.R.B., J.D., C.D.), Department of Neurology and Penn Memory Center (M.H., D.A.W.), and Department of Biostatistics and Epidemiology (H.S.), University of Pennsylvania, Philadelphia; Department of Psychiatry (M.H., D.J., H.J.G.), Institute for Community Medicine (M.H., H.V., W.H.), and Department of Neurology (U.S.), University of Greifswald, Germany; Department of Neurology (J.B.T.), Houston Methodist Hospital, TX; German Center for Neurodegenerative Diseases (W.H., H.J.G.), Rostock/Greifswald, Germany; and Laboratory of Behavioral Neuroscience (S.M.R.), National Institute on Aging, Baltimore, MD.
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Guray Erus
From the Center for Biomedical Image Computing and Analytics (M.H., A.S., G.E., N.R.B., J.D., C.D.), Department of Neurology and Penn Memory Center (M.H., D.A.W.), and Department of Biostatistics and Epidemiology (H.S.), University of Pennsylvania, Philadelphia; Department of Psychiatry (M.H., D.J., H.J.G.), Institute for Community Medicine (M.H., H.V., W.H.), and Department of Neurology (U.S.), University of Greifswald, Germany; Department of Neurology (J.B.T.), Houston Methodist Hospital, TX; German Center for Neurodegenerative Diseases (W.H., H.J.G.), Rostock/Greifswald, Germany; and Laboratory of Behavioral Neuroscience (S.M.R.), National Institute on Aging, Baltimore, MD.
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jon B. Toledo
From the Center for Biomedical Image Computing and Analytics (M.H., A.S., G.E., N.R.B., J.D., C.D.), Department of Neurology and Penn Memory Center (M.H., D.A.W.), and Department of Biostatistics and Epidemiology (H.S.), University of Pennsylvania, Philadelphia; Department of Psychiatry (M.H., D.J., H.J.G.), Institute for Community Medicine (M.H., H.V., W.H.), and Department of Neurology (U.S.), University of Greifswald, Germany; Department of Neurology (J.B.T.), Houston Methodist Hospital, TX; German Center for Neurodegenerative Diseases (W.H., H.J.G.), Rostock/Greifswald, Germany; and Laboratory of Behavioral Neuroscience (S.M.R.), National Institute on Aging, Baltimore, MD.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Deborah Janowitz
From the Center for Biomedical Image Computing and Analytics (M.H., A.S., G.E., N.R.B., J.D., C.D.), Department of Neurology and Penn Memory Center (M.H., D.A.W.), and Department of Biostatistics and Epidemiology (H.S.), University of Pennsylvania, Philadelphia; Department of Psychiatry (M.H., D.J., H.J.G.), Institute for Community Medicine (M.H., H.V., W.H.), and Department of Neurology (U.S.), University of Greifswald, Germany; Department of Neurology (J.B.T.), Houston Methodist Hospital, TX; German Center for Neurodegenerative Diseases (W.H., H.J.G.), Rostock/Greifswald, Germany; and Laboratory of Behavioral Neuroscience (S.M.R.), National Institute on Aging, Baltimore, MD.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David A. Wolk
From the Center for Biomedical Image Computing and Analytics (M.H., A.S., G.E., N.R.B., J.D., C.D.), Department of Neurology and Penn Memory Center (M.H., D.A.W.), and Department of Biostatistics and Epidemiology (H.S.), University of Pennsylvania, Philadelphia; Department of Psychiatry (M.H., D.J., H.J.G.), Institute for Community Medicine (M.H., H.V., W.H.), and Department of Neurology (U.S.), University of Greifswald, Germany; Department of Neurology (J.B.T.), Houston Methodist Hospital, TX; German Center for Neurodegenerative Diseases (W.H., H.J.G.), Rostock/Greifswald, Germany; and Laboratory of Behavioral Neuroscience (S.M.R.), National Institute on Aging, Baltimore, MD.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Haochang Shou
From the Center for Biomedical Image Computing and Analytics (M.H., A.S., G.E., N.R.B., J.D., C.D.), Department of Neurology and Penn Memory Center (M.H., D.A.W.), and Department of Biostatistics and Epidemiology (H.S.), University of Pennsylvania, Philadelphia; Department of Psychiatry (M.H., D.J., H.J.G.), Institute for Community Medicine (M.H., H.V., W.H.), and Department of Neurology (U.S.), University of Greifswald, Germany; Department of Neurology (J.B.T.), Houston Methodist Hospital, TX; German Center for Neurodegenerative Diseases (W.H., H.J.G.), Rostock/Greifswald, Germany; and Laboratory of Behavioral Neuroscience (S.M.R.), National Institute on Aging, Baltimore, MD.
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nick R. Bryan
From the Center for Biomedical Image Computing and Analytics (M.H., A.S., G.E., N.R.B., J.D., C.D.), Department of Neurology and Penn Memory Center (M.H., D.A.W.), and Department of Biostatistics and Epidemiology (H.S.), University of Pennsylvania, Philadelphia; Department of Psychiatry (M.H., D.J., H.J.G.), Institute for Community Medicine (M.H., H.V., W.H.), and Department of Neurology (U.S.), University of Greifswald, Germany; Department of Neurology (J.B.T.), Houston Methodist Hospital, TX; German Center for Neurodegenerative Diseases (W.H., H.J.G.), Rostock/Greifswald, Germany; and Laboratory of Behavioral Neuroscience (S.M.R.), National Institute on Aging, Baltimore, MD.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jimit Doshi
From the Center for Biomedical Image Computing and Analytics (M.H., A.S., G.E., N.R.B., J.D., C.D.), Department of Neurology and Penn Memory Center (M.H., D.A.W.), and Department of Biostatistics and Epidemiology (H.S.), University of Pennsylvania, Philadelphia; Department of Psychiatry (M.H., D.J., H.J.G.), Institute for Community Medicine (M.H., H.V., W.H.), and Department of Neurology (U.S.), University of Greifswald, Germany; Department of Neurology (J.B.T.), Houston Methodist Hospital, TX; German Center for Neurodegenerative Diseases (W.H., H.J.G.), Rostock/Greifswald, Germany; and Laboratory of Behavioral Neuroscience (S.M.R.), National Institute on Aging, Baltimore, MD.
MSc
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Henry Völzke
From the Center for Biomedical Image Computing and Analytics (M.H., A.S., G.E., N.R.B., J.D., C.D.), Department of Neurology and Penn Memory Center (M.H., D.A.W.), and Department of Biostatistics and Epidemiology (H.S.), University of Pennsylvania, Philadelphia; Department of Psychiatry (M.H., D.J., H.J.G.), Institute for Community Medicine (M.H., H.V., W.H.), and Department of Neurology (U.S.), University of Greifswald, Germany; Department of Neurology (J.B.T.), Houston Methodist Hospital, TX; German Center for Neurodegenerative Diseases (W.H., H.J.G.), Rostock/Greifswald, Germany; and Laboratory of Behavioral Neuroscience (S.M.R.), National Institute on Aging, Baltimore, MD.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ulf Schminke
From the Center for Biomedical Image Computing and Analytics (M.H., A.S., G.E., N.R.B., J.D., C.D.), Department of Neurology and Penn Memory Center (M.H., D.A.W.), and Department of Biostatistics and Epidemiology (H.S.), University of Pennsylvania, Philadelphia; Department of Psychiatry (M.H., D.J., H.J.G.), Institute for Community Medicine (M.H., H.V., W.H.), and Department of Neurology (U.S.), University of Greifswald, Germany; Department of Neurology (J.B.T.), Houston Methodist Hospital, TX; German Center for Neurodegenerative Diseases (W.H., H.J.G.), Rostock/Greifswald, Germany; and Laboratory of Behavioral Neuroscience (S.M.R.), National Institute on Aging, Baltimore, MD.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wolfgang Hoffmann
From the Center for Biomedical Image Computing and Analytics (M.H., A.S., G.E., N.R.B., J.D., C.D.), Department of Neurology and Penn Memory Center (M.H., D.A.W.), and Department of Biostatistics and Epidemiology (H.S.), University of Pennsylvania, Philadelphia; Department of Psychiatry (M.H., D.J., H.J.G.), Institute for Community Medicine (M.H., H.V., W.H.), and Department of Neurology (U.S.), University of Greifswald, Germany; Department of Neurology (J.B.T.), Houston Methodist Hospital, TX; German Center for Neurodegenerative Diseases (W.H., H.J.G.), Rostock/Greifswald, Germany; and Laboratory of Behavioral Neuroscience (S.M.R.), National Institute on Aging, Baltimore, MD.
MD, MPH
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Susan M. Resnick
From the Center for Biomedical Image Computing and Analytics (M.H., A.S., G.E., N.R.B., J.D., C.D.), Department of Neurology and Penn Memory Center (M.H., D.A.W.), and Department of Biostatistics and Epidemiology (H.S.), University of Pennsylvania, Philadelphia; Department of Psychiatry (M.H., D.J., H.J.G.), Institute for Community Medicine (M.H., H.V., W.H.), and Department of Neurology (U.S.), University of Greifswald, Germany; Department of Neurology (J.B.T.), Houston Methodist Hospital, TX; German Center for Neurodegenerative Diseases (W.H., H.J.G.), Rostock/Greifswald, Germany; and Laboratory of Behavioral Neuroscience (S.M.R.), National Institute on Aging, Baltimore, MD.
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hans J. Grabe
From the Center for Biomedical Image Computing and Analytics (M.H., A.S., G.E., N.R.B., J.D., C.D.), Department of Neurology and Penn Memory Center (M.H., D.A.W.), and Department of Biostatistics and Epidemiology (H.S.), University of Pennsylvania, Philadelphia; Department of Psychiatry (M.H., D.J., H.J.G.), Institute for Community Medicine (M.H., H.V., W.H.), and Department of Neurology (U.S.), University of Greifswald, Germany; Department of Neurology (J.B.T.), Houston Methodist Hospital, TX; German Center for Neurodegenerative Diseases (W.H., H.J.G.), Rostock/Greifswald, Germany; and Laboratory of Behavioral Neuroscience (S.M.R.), National Institute on Aging, Baltimore, MD.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christos Davatzikos
From the Center for Biomedical Image Computing and Analytics (M.H., A.S., G.E., N.R.B., J.D., C.D.), Department of Neurology and Penn Memory Center (M.H., D.A.W.), and Department of Biostatistics and Epidemiology (H.S.), University of Pennsylvania, Philadelphia; Department of Psychiatry (M.H., D.J., H.J.G.), Institute for Community Medicine (M.H., H.V., W.H.), and Department of Neurology (U.S.), University of Greifswald, Germany; Department of Neurology (J.B.T.), Houston Methodist Hospital, TX; German Center for Neurodegenerative Diseases (W.H., H.J.G.), Rostock/Greifswald, Germany; and Laboratory of Behavioral Neuroscience (S.M.R.), National Institute on Aging, Baltimore, MD.
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Citation
White matter lesions
Spatial heterogeneity, links to risk factors, cognition, genetics, and atrophy
Mohamad Habes, Aristeidis Sotiras, Guray Erus, Jon B. Toledo, Deborah Janowitz, David A. Wolk, Haochang Shou, Nick R. Bryan, Jimit Doshi, Henry Völzke, Ulf Schminke, Wolfgang Hoffmann, Susan M. Resnick, Hans J. Grabe, Christos Davatzikos
Neurology Aug 2018, 10.1212/WNL.0000000000006116; DOI: 10.1212/WNL.0000000000006116

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
1003

Share

  • Article
  • Figures & Data
  • Info & Disclosures
Loading

Article Information

10.1212/WNL.0000000000006116
DOI: 
https://doi.org/10.1212/WNL.0000000000006116
PubMed: 
30076276

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received July 28, 2017
  • Accepted in final form June 4, 2018
  • First Published August 3, 2018.

Article Versions

  • You are currently viewing a Previous version of this article (August 3, 2018 - 12:45).
  • View the most recent version of this article
Copyright & Usage: 
© 2018 American Academy of Neurology

Author Disclosures

    1. Mohamad Habes, PhD,
    2. Aristeidis Sotiras, PhD,
    3. Guray Erus, PhD,
    4. Jon B. Toledo, MD,
    5. Deborah Janowitz, MD,
    6. David A. Wolk, MD,
    7. Haochang Shou, PhD,
    8. Nick R. Bryan, MD,
    9. Jimit Doshi, MSc,
    10. Henry Völzke, MD,
    11. Ulf Schminke, MD,
    12. Wolfgang Hoffmann, MD, MPH,
    13. Susan M. Resnick, PhD‡,
    14. Hans J. Grabe, MD‡ and
    15. Christos Davatzikos, PhD‡
  1. Mohamad Habes, PhD,
  2. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NIH (grant no. 1RF1AG054409)

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. Dr. Mohamad Habes was supported in part by ?Alfried Krupp von Bohlen und Halbach? foundation. This work has been supported in part by The Allen H. and Selma W. Berkman Charitable Trust (Accelerating Research on Vascular Dementia)

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. Aristeidis Sotiras, PhD,
  4. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. (1) Method and device for efficient parallel message computation for maximum a posteriori inference

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. This work has been supported in part by NIH (grant no. 1RF1AG054409). Stock/Stock Options, Medical Equipment & Materials: (1) TheraPanacea (<1year)

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. Guray Erus, PhD,
  6. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. This work has been supported in part by NIH (grant no. 1RF1AG054409)

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  7. Jon B. Toledo, MD,
  8. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. Eli-Lilly

    Research Support, Government Entities:
    1. NIH

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  9. Deborah Janowitz, MD,
  10. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  11. David A. Wolk, MD,
  12. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. 1. GE Healthcare, meeting registration

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. Merck Eli Lilly Janssen

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. 1. Eli Lilly, Inc 2. AVID Radiopharmaceuticals 3. Merck 4. Biogen 5. Functional Neuromodulation

    Research Support, Government Entities:
    1. 1. NIH, AG040271, PI, 08/1/12-05/31/17 2. NIH, AG010124, Co-I, 09/30/90 - 06/30/16 3. NIH, EB016923, Co-I, 05/1/14 - 4/30/16 4. NIH, EB017255, Co-I, 08/01/2014 - 07/31/2019 5. NIH, AG047866, Co-I, 08/20/20015- 07/31/2019 6. NIH, AG024904, Site-PI, 09/30/2004 - 7/31/2016 7. NIH, AG055005, PI, 3/1/2017 - 2/28/2022 8. NIH, AG058065, MPI, 12/1/17 ? 11/30/22 9. NIH, AG054435, MPI, 04/01/17 ? 03/31/21 10. NIH, AG054409, MPI, 04/15/2017 ? 03/31/2022

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. 1. Michael J. Fox/Alzheimer?s Association 2. Alzheimer's Association

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  13. Haochang Shou, PhD,
  14. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. (1) Scientific reports, editorial member, 2015-present

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  15. Nick R. Bryan, MD,
  16. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NIH; PI Longitudinal Studies of Coronary Artery Risk Development in Young Adults; MRI Reading Center (CARDIA) 000501394-sc007, 2008-2017

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. GalileoCDS, Inc; founder, board member; stock equity; 2015 Stock/Stock Options, Medical Equipment & Materials: GalileoCDS, Inc; founder, board member; stock equity; 2015

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  17. Jimit Doshi, MSc,
  18. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  19. Henry Völzke, MD,
  20. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. BMBF

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  21. Ulf Schminke, MD,
  22. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. I received travel expenses and/or honoraria for lectures or educational activities not funded by industry and I received speaker?s honoraria from UCB Pharma GmbH, Germany.

    Editorial Boards:
    1. Member of the Editorial board of Cerebrovascular Diseases and Journal of Clinical Ultrasound

    Patents:
    1. NONE

    Publishing Royalties:
    1. I received royalties from the publication of the book Podrecznik diagnostyki ultrasonograficznej w neurologii from Czelej Publisher, Poland, in 2011, and from the book SOP's Neurophysiologische Diagnostik from Thieme Publisher, Germany, in 2018.

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. My research activities were funded Siemens Healthcare, Erlangen, Germany.

    Research Support, Government Entities:
    1. My research activities were funded by the National Institute of Neurological Disorders and Stroke (subaward #A08580 M10A10647), the Federal Ministry of Education and Research, Germany (grant #03IS2061A), the Federal State of Mecklenburg-West Pomerania, Germany.

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  23. Wolfgang Hoffmann, MD, MPH,
  24. Scientific Advisory Boards:
    1. (1) non-profit External Scientific Advisory Board of the centralized Interdisciplinary Bank of Biomaterials and Data W?rzburg (ibdw) (2) External scientific Advisory Board Hamburg City Health Study (HCHS)

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. commercial, monetary honorarium, speaker honorarium at Siemens Roadshow 2013, Roche Symposia on CRISP Lung Cancer Registry (total 4 times 2016-2018)

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. (1)Federal ministry of Social Affairs of Mecklenburg- Western Pomerania, Summative Evaluation Kif?g M-V, PI, 2012-2018; PI (2) Federal Ministry of Economy, Work and Health, Exemplary health care solutions for challenged regions in M-V (2016-2020)

    Research Support, Academic Entities:
    1. (1) BMBF (Ministry of Science), Feasibility- Studien/Pretest Nationale Kohorte: Zentrales Datenmanagement, PI, 2010-2013 (2)BMBF (Ministry of Science), Gesundheitsregion Ostseek?ste - HICARE; Projektfeld 4: "IT & Epidemiologie", PI, 2011-2014 (3) BMBF (Ministry of Science), GANI_MED Teilprojekt SB3: Medizininformatik (Kohortenmanagement und Forschungsplattform), PI, 2010-2014 (4)BMBF (Ministry of Science), Integrated Data Management and telemedical Monitoring (DZHK: PI.4 IT), PI, 2011-2015 (5) DFG, Wissenschaftliche Literaturversorgungs- und Informationssysteme (LIS) - Modulares Unterst?tzungssystem zur Planung und Implementierung eines zentralen Datenmanagements f?r Forschungsprojekte der Gesundheitsforschung, PI, 2012-2015

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  25. Susan M. Resnick, PhD‡,
  26. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. Dr. Resnick has received travel reimbursement for her participation on the international advisory board for the Canadian Consortium on Neurodegeneration in Aging; Spouse has consulted and received travel reimbursement and honoraria from Dart Neuroscience and Roche and has received travel reimbursement and honoraria from University of California, Los Angeles

    Editorial Boards:
    1. Brain and Cognition (Action Editor)

    Patents:
    1. spouse has patent pending on Photoacoustic Voltage Sensitive Dyes for In Vivo Imaging

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. spouse - consultant Dart Neuroscience and Roche

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. spouse - grant and/or contract support unrelated to this study: Addex, Avid, Dart Neuroscience, Johnson and Johnson, Intracellular, Lundbeck, Pfizer, Roche, Takeda

    Research Support, Government Entities:
    1. NIA Intramural Research Program - Senior Investigator; spouse has NIH and CDC grants and contracts managed through Johns Hopkins University

    Research Support, Academic Entities:
    1. spouse - employed by Johns Hopkins University

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  27. Hans J. Grabe, MD‡ and
  28. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. Fresenius Medical Care

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. Janssen

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. Fresenius Medical Care

    Research Support, Government Entities:
    1. BMBF, DFG

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. Damp

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  29. Christos Davatzikos, PhD‡
  30. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  1. From the Center for Biomedical Image Computing and Analytics (M.H., A.S., G.E., N.R.B., J.D., C.D.), Department of Neurology and Penn Memory Center (M.H., D.A.W.), and Department of Biostatistics and Epidemiology (H.S.), University of Pennsylvania, Philadelphia; Department of Psychiatry (M.H., D.J., H.J.G.), Institute for Community Medicine (M.H., H.V., W.H.), and Department of Neurology (U.S.), University of Greifswald, Germany; Department of Neurology (J.B.T.), Houston Methodist Hospital, TX; German Center for Neurodegenerative Diseases (W.H., H.J.G.), Rostock/Greifswald, Germany; and Laboratory of Behavioral Neuroscience (S.M.R.), National Institute on Aging, Baltimore, MD.
  1. Correspondence
    Dr. Habes habesm{at}uphs.upenn.edu

Article usage

Article usage: August 2018 to August 2023

AbstractFullPdfSource
Aug 20181033164Highwire
Sep 20186379072Highwire
Oct 20183083829Highwire
Nov 20182351211Highwire
Dec 2018214149Highwire
Jan 20192011520Highwire
Feb 20191862512Highwire
Mar 20192581911Highwire
Apr 2019358139Highwire
May 20192981318Highwire
Jun 20192571622Highwire
Jul 20192631820Highwire
Aug 2019281719Highwire
Sep 2019149419Highwire
Oct 20191731228Highwire
Nov 2019198849Highwire
Dec 2019145344Highwire
Jan 2020176441Highwire
Feb 20201961450Highwire
Mar 20201531131Highwire
Apr 2020121420Highwire
May 2020122018Highwire
Jun 2020102625Highwire
Jul 2020131122Highwire
Aug 202098217Highwire
Sep 2020198921Highwire
Oct 2020183414Highwire
Nov 2020182722Highwire
Dec 2020196316Highwire
Jan 2021203228Highwire
Feb 2021159515Highwire
Mar 2021197420Highwire
Apr 2021125316Highwire
May 202115826Highwire
Jun 20211661111Highwire
Jul 2021158310Highwire
Aug 202116916Highwire
Sep 202120168Highwire
Oct 2021292610Highwire
Nov 202124078Highwire
Dec 202122027Highwire
Jan 2022221914Highwire
Feb 2022201411Highwire
Mar 202219257Highwire
Apr 202212210Highwire
May 202210655Highwire
Jun 20229155Highwire
Jul 20229389Highwire
Aug 20227632Highwire
Sep 202212044Highwire
Oct 20221071212Highwire
Nov 2022118410Highwire
Dec 202211620Highwire
Jan 202310754Highwire
Feb 20238832Highwire
Mar 20239955Highwire
Apr 20235813Highwire
May 20238154Highwire
Jun 20238112Highwire
Jul 20237912Highwire
Aug 20237024Highwire

Cited By...

  • 71 Citations
  • Google Scholar

Letters: Rapid online correspondence

No comments have been published for this article.

REQUIREMENTS

You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
  • Figures & Data
  • Info & Disclosures
Advertisement

Association Between Fluctuations in Blood Lipid Levels Over Time With Incident Alzheimer Disease and Alzheimer Disease–Related Dementias

Dr. Sevil Yaşar and Dr. Behnam Sabayan

► Watch

Topics Discussed

  • All Cerebrovascular disease/Stroke
  • All epidemiology
  • All Imaging
  • All Cognitive Disorders/Dementia
  • Vascular dementia

Alert Me

  • Alert me when eletters are published

Recommended articles

  • Article
    Dissociable influences of APOE ε4 and polygenic risk of AD dementia on amyloid and cognition
    Tian Ge, Mert R. Sabuncu, Jordan W. Smoller et al.
    Neurology, March 28, 2018
  • Article
    Polygenic risk of Alzheimer disease is associated with early- and late-life processes
    Elizabeth C. Mormino, Reisa A. Sperling, Avram J. Holmes et al.
    Neurology, July 06, 2016
  • Article
    Polygenic risk of ischemic stroke is associated with cognitive ability
    Sarah E. Harris, Rainer Malik, Riccardo Marioni et al.
    Neurology, December 22, 2015
  • Article
    Genetic overlap and causal inferences between kidney function and cerebrovascular disease
    Sandro Marini, Marios K. Georgakis, Jaeyoon Chung et al.
    Neurology, May 21, 2020
Neurology: 101 (13)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Education
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2023 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise