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Long-term brain effects of solvent exposure

  • Heikki Savolainen, Professor, Dept. of Occup. Safety & Hlth, Tampere, Finlandheikki.savolainen@stm.fi
Submitted May 27, 2014

This elegant paper by Sabbath et al. confirms the earlier notion that all effects of chronic solvent toxicity do not disappear during cessation of the exposure. [1] The differences in the toxic properties of the solvent molecules may be decisive in the various clinical pictures. [2,3] The mechanisms may be related to the loss of cortical microcolumns, reactive gliosis, and even demyelination. It seems that even the newer water miscible solvents show toxic potential. [4]

1.Sabbath EL, Gutierrez L, Okechukwu CA, et al. Time may not fully attenuate solvent-associated cognitive deficits in highly exposed workers. Neurology 2014; 82: 1716-1723.

2. Savolainen H. Neurotoxicity of industrial chemicals and contaminants: Aspects of biochemical mechanisms and effects. Arch Toxicol 1982; Suppl 5: 71

3. Savolainen H. Toxicological mechanisms in acute and chronic nervous system degeneration. Acta neurol Scandinav 1982;66; Suppl 92: 23.

4. Laitinen J, Liesivuori J, Savolainen H. Urinary NAG and GAG as biomarkers of renal effects in exposure to 2-alkoxyalcohols and their acetates. J Occup Environ Med 1998;40: 595.

For disclosures, contact the editorial office at journal@neurology.org.

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Neurology | Print ISSN:0028-3878
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