This elegant paper by Sabbath et al. confirms the earlier notion that all effects of chronic solvent toxicity do not disappear during cessation of the exposure. [1] The differences in the toxic properties of the solvent molecules may be decisive in the various clinical pictures. [2,3] The mechanisms may be related to the loss of cortical microcolumns, reactive gliosis, and even demyelination. It seems that even the newer water miscible solvents show toxic potential. [4]
1.Sabbath EL, Gutierrez L, Okechukwu CA, et al. Time may not fully attenuate solvent-associated cognitive deficits in highly exposed workers. Neurology 2014; 82: 1716-1723.
2. Savolainen H. Neurotoxicity of industrial chemicals and contaminants: Aspects of biochemical mechanisms and effects. Arch Toxicol 1982; Suppl 5: 71
3. Savolainen H. Toxicological mechanisms in acute and chronic nervous system degeneration. Acta neurol Scandinav 1982;66; Suppl 92: 23.
4. Laitinen J, Liesivuori J, Savolainen H. Urinary NAG and GAG as biomarkers of renal effects in exposure to 2-alkoxyalcohols and their acetates. J Occup Environ Med 1998;40: 595.
For disclosures, contact the editorial office at journal@neurology.org.
This elegant paper by Sabbath et al. confirms the earlier notion that all effects of chronic solvent toxicity do not disappear during cessation of the exposure. [1] The differences in the toxic properties of the solvent molecules may be decisive in the various clinical pictures. [2,3] The mechanisms may be related to the loss of cortical microcolumns, reactive gliosis, and even demyelination. It seems that even the newer water miscible solvents show toxic potential. [4]
1.Sabbath EL, Gutierrez L, Okechukwu CA, et al. Time may not fully attenuate solvent-associated cognitive deficits in highly exposed workers. Neurology 2014; 82: 1716-1723.
2. Savolainen H. Neurotoxicity of industrial chemicals and contaminants: Aspects of biochemical mechanisms and effects. Arch Toxicol 1982; Suppl 5: 71
3. Savolainen H. Toxicological mechanisms in acute and chronic nervous system degeneration. Acta neurol Scandinav 1982;66; Suppl 92: 23.
4. Laitinen J, Liesivuori J, Savolainen H. Urinary NAG and GAG as biomarkers of renal effects in exposure to 2-alkoxyalcohols and their acetates. J Occup Environ Med 1998;40: 595.
For disclosures, contact the editorial office at journal@neurology.org.