BrigitteWildemann, Division of Molecular Neuroimmunolgy, Department of Neurology, University of Heidelberg
Published September 16, 2009
We thank Dr. Bomprezzi for his encouraging comments on our report describing a case of severe ADEM following booster vaccination with the polyvalent HPV vaccine Gardasil®.
Dr. Bomprezzi reports two young females who developed a demyelinating syndrome within four weeks of vaccination with Gardasil® and later met criteria for multiple sclerosis. This observation supplements previous reports on the concurrence of an inflammatory CNS disorder and administration of the HPV vaccine in five young women. [2] Contrary to our findings, four of these five patients had already presented with symptoms suggestive of a first demyelinating event prior to vaccination.
As the patients mentioned by Dr. Bomprezzi also developed neurologic symptoms only after contact with the vaccine, it would be interesting to know their case histories in detail.
Disclosure: Dr. Wildemann received research support from the German Federal Ministry of Education and Research and research support and honoraria for speaking engagements or attendance of scientific meetings from Biogen Idec, Bayer Vital, Merck Serono, TEVA/Aventis, and Biotest.
We thank Dr. Bomprezzi for his encouraging comments on our report describing a case of severe ADEM following booster vaccination with the polyvalent HPV vaccine Gardasil®.
Dr. Bomprezzi reports two young females who developed a demyelinating syndrome within four weeks of vaccination with Gardasil® and later met criteria for multiple sclerosis. This observation supplements previous reports on the concurrence of an inflammatory CNS disorder and administration of the HPV vaccine in five young women. [2] Contrary to our findings, four of these five patients had already presented with symptoms suggestive of a first demyelinating event prior to vaccination.
As the patients mentioned by Dr. Bomprezzi also developed neurologic symptoms only after contact with the vaccine, it would be interesting to know their case histories in detail.
Disclosure: Dr. Wildemann received research support from the German Federal Ministry of Education and Research and research support and honoraria for speaking engagements or attendance of scientific meetings from Biogen Idec, Bayer Vital, Merck Serono, TEVA/Aventis, and Biotest.