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Reply to Jabre et al

  • Ted VanItallie, Columbia University, PO Box 775 Boca Grande, FL 33921-0775tedvani@ewol.com
Submitted June 27, 2005

We thank Jabre et al for their comments. The enhancing effect of weight loss on levodopa efficacy is well taken. Weight loss could well have contributed to the improvement exhibited by our patients. However, one of the patients who improved was not on any anti-Parkinson medication.

Ketone esters for oral administration should become available for clinical trial in a year or two. Use of such preparations to induce hyperketonemia in patients with PD should help us determine whether it is hyperketonemia or some other attribute of the hyperketogenic diet that is responsible for the type of clinical improvement we observed.

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Neurology | Print ISSN:0028-3878
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