Request for Correction to "Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease" by Fitzmaurice et al.
William J.Burke, Professor Emeritus, Saint Louis University Medical School[email protected]
St Louis, MO
Submitted May 22, 2014
In their article on aldehyde dehydrogenase variation and effect on pesticides associated with Parkinson disease (PD) [1], Fitzmaurice et al.'s conclusions are based on the findings that 3,4-dihydroxyphenylacetaldehyde (DOPAL) is toxic to dopamine neurons. They state on p. 425 : "We previously reported that pesticide-induced ALDH inhibition can lead to the accumulation of toxic aldehydes (e.g. DOPAL) and result in dopaminergic cell death. (11)" Reference 11 [2] is an earlier study by these authors. There is no direct study of DOPAL or its toxicity in this paper. The correct attributions to DOPAL toxicity are in vitro [3] and in vivo. [4] A correction should be published.
1. Fitzmaurice AG, Rhodes SL, Cockburn M, Ritz B, Bronstein JM. Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease. Neurology 2014;82:419-426.
2. Fitzmaurice AG, Rhodes SL, Lulla A, et al. Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease. Proc Natl Acad Sci USA 2013;110:636-641.
3. Kristal BS, Conway AD, Brown AM, Jain JC, Ulluci PA, Li SW, Burke WJ. Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria. Free Radical Biology & Medicine 2001;30:924-931.
4. Burke WJ, Li SW, Williams EA, Nonneman R, Zahm DS. 3,4-Dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo: implications for Parkinson's disease pathogenesis. 2003;989:205-213.
In their article on aldehyde dehydrogenase variation and effect on pesticides associated with Parkinson disease (PD) [1], Fitzmaurice et al.'s conclusions are based on the findings that 3,4-dihydroxyphenylacetaldehyde (DOPAL) is toxic to dopamine neurons. They state on p. 425 : "We previously reported that pesticide-induced ALDH inhibition can lead to the accumulation of toxic aldehydes (e.g. DOPAL) and result in dopaminergic cell death. (11)" Reference 11 [2] is an earlier study by these authors. There is no direct study of DOPAL or its toxicity in this paper. The correct attributions to DOPAL toxicity are in vitro [3] and in vivo. [4] A correction should be published.
1. Fitzmaurice AG, Rhodes SL, Cockburn M, Ritz B, Bronstein JM. Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease. Neurology 2014;82:419-426.
2. Fitzmaurice AG, Rhodes SL, Lulla A, et al. Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease. Proc Natl Acad Sci USA 2013;110:636-641.
3. Kristal BS, Conway AD, Brown AM, Jain JC, Ulluci PA, Li SW, Burke WJ. Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria. Free Radical Biology & Medicine 2001;30:924-931.
4. Burke WJ, Li SW, Williams EA, Nonneman R, Zahm DS. 3,4-Dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo: implications for Parkinson's disease pathogenesis. 2003;989:205-213.
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