Dr. Burke is a key investigator in this field highlighting the potential importance of DOPAL in PD pathogenesis. It was his work and others that we referenced that led us to pursue ALDH activity in our study of pesticides. We agree that we did not provide direct measurements of DOPAL but provided several lines of evidence that these pesticides can lead to DOPAL accumulation. Our prior work [1] focused on such pesticide-induced effects while others' studies have not.
1.Fitzmaurice AG, Rhodes SL, Lulla A, et al. Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease. Proc Natl Acad Sci USA 2013;110:636-641.
For disclosures, please contact the editorial office at journal@neurology.org.
Please note that a Correction will be published in a future issue.
Dr. Burke is a key investigator in this field highlighting the potential importance of DOPAL in PD pathogenesis. It was his work and others that we referenced that led us to pursue ALDH activity in our study of pesticides. We agree that we did not provide direct measurements of DOPAL but provided several lines of evidence that these pesticides can lead to DOPAL accumulation. Our prior work [1] focused on such pesticide-induced effects while others' studies have not.
1.Fitzmaurice AG, Rhodes SL, Lulla A, et al. Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease. Proc Natl Acad Sci USA 2013;110:636-641.
For disclosures, please contact the editorial office at journal@neurology.org.
Please note that a Correction will be published in a future issue.