PT  - JOURNAL ARTICLE
AU  - HARRIS BONNETTE
AU  - ROBERT ROELOFS
AU  - WILLIAM H. OLSON
TI  - Multicore disease
AID  - 10.1212/WNL.24.11.1039
DP  - 1974 Nov 01
TA  - Neurology
PG  - 1039--1039
VI  - 24
IP  - 11
4099  - http://n.neurology.org/content/24/11/1039.short
4100  - http://n.neurology.org/content/24/11/1039.full
SO  - Neurology1974 Nov 01; 24
AB  - A 46-year-old white man had a 12-year history of progressive, symmetrical proximal weakness. Changes consistent with a myopathy were seen on electromyography, along with normal nerve conduction velocities. Serum creatine phosphokinase was slightly elevated. Muscle biopsies showed type I fiber predominance and focal areas of absent or increased oxidative enzyme activity, with other fibers containing focal areas of absent myofibril-lar ATPase activity. Serial sections showed little correlation between abnormalities demonstrated with oxidative enzymes and ATPase. Ultrastruc-tural changes included focal disruption of myofibrils and Z-band streaming. Similar morphologic changles have previously been described in a congenital, nonprogressive myopathy.