PT  - JOURNAL ARTICLE
AU  - ROBERT P. LISAK
AU  - PETER O. BEHAN
AU  - BURTON ZWEIMAN
AU  - TARANATH SHETTY
TI  - Cell‐mediated immunity to myelin basic protein in acute disseminated encephalomyelitis
AID  - 10.1212/WNL.24.6.560
DP  - 1974 Jun 01
TA  - Neurology
PG  - 560--560
VI  - 24
IP  - 6
4099  - http://n.neurology.org/content/24/6/560.short
4100  - http://n.neurology.org/content/24/6/560.full
SO  - Neurology1974 Jun 01; 24
AB  - Encephalitogenic myelin basic protein, the antigen responsible for induction of experimental allergic encephalomyelitis in animals, induced a significant proliferative lymphocyte response in the cells of five of eight patients in the acute stages of acute disseminated encephalomyelitis, a possible clinical counterpart of experimental allergic encephalomyelitis. No significant response was noted in patients recovered from acute disseminated encephalomyelitis nor in patients with multiple sclerosis or other neurologic diseases nor in normal controls. No circulating antibody to myelin basic protein was detected in the sera of any patients or controls. These findings suggest that cell-mediated immunity to myelin basic protein is a concomitant of acute disseminated encephalomyelitis and may be important in the pathogenesis of the disease.