PT  - JOURNAL ARTICLE
AU  - LESLIE I. WOLFSON
AU  - ROBERT KATZMAN
AU  - ANTHONY ESCRIVA
TI  - Clearance of amine metabolites from the cerebrospinal fluid
AID  - 10.1212/WNL.24.8.772
DP  - 1974 Aug 01
TA  - Neurology
PG  - 772--772
VI  - 24
IP  - 8
4099  - http://n.neurology.org/content/24/8/772.short
4100  - http://n.neurology.org/content/24/8/772.full
SO  - Neurology1974 Aug 01; 24
AB  - The clearance of 5-hydroxyindoleacetic acid from the cerebrospinal fluid of cats was studied. Clearances were low during ventriculocisternal perfusions. The clearances were five times greater during spinal subarachnoid perfusions and 10 times greater during cortical subarachnoid perfusions. The cortical subarachnoid clearances can be resolved into a saturable mediated transport mechanism and a diffusional component. The mediated transport Component was blocked both in this system and in the spinal subarachnoid system by pretreatment with probenecid. A mechanism consistent with the above data is proposed for the clearance of cerebrospinal fluid monoamine metabolites from the central nervous system.