RT Journal Article
SR Electronic
T1 Evidence of subnormal function of association cortex in presenile dementia
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 964
OP 964
DO 10.1212/WNL.25.10.964
VO 25
IS 10
A1 INGVAR, OAVID H.
A1 RISBERG, JARL
A1 SCHWARTZ, MARTIN S.
YR 1975
UL http://n.neurology.org/content/25/10/964.abstract
AB Regional cerebral blood flow (rCBF) was measured in 23 patients with organic dementia (17 patients with Alzheimer's disease and six with low-pressure hydrocephalus [LPH]). The flow of gray matter was significantly reduced, especially in occipito-parieto-temporal regions, as well as frontally in some patients. During activation with psychologic tests, reading, etc., the flow augmentation in the association areas in the demented patients was not as marked as in nondemented controls. Instead, in some patients, a flow diminution was recorded in the same regions (intellectual steal). Organic dementia appears to be accompanied by a low activity in the association cortex and a reduced ability to activate these regions during mental effort.