RT Journal Article
SR Electronic
T1 Glioblastoma multiforme and the meningeal syndrome
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1071
OP 1071
DO 10.1212/WNL.26.11.1071
VO 26
IS 11
A1 BERNAT, JAMES L.
YR 1976
UL http://n.neurology.org/content/26/11/1071.abstract
AB Brain tumors rarely may produce acute sterile meningitis (the meningeal syndrome) resulting from the spillage of blood, lipid products of tumor necrosis, or malignant cells into the cerebrospinal fluid (CSF). The frequency of the associated meningeal syndrome is a function of tumor type and of the proximity of tumor necrosis to the ventricles. The meningeal syndromes of lipid-induced chemical inflammation are seen most commonly with epidermoids, craniopharyngiomas, and infarcted pituitary adenomas. I report a patient with the rare association of the meningeal syndrome with glioblastoma multiforme. The lipid irritants of glioblastomas and craniopharyngiomas are similar chemically and can be detected in the CSF. The anti-inflammatory and immunosuppressant properties of steroids provide a rational basis for their efficacy in treatment of the syndrome.