PT  - JOURNAL ARTICLE
AU  - SUSAN P. COLBY
AU  - WILLIAM SHEREMATA
AU  - BARBARA BAIN
AU  - EDWIN H. EYLAR
TI  - Cellular hypersensitivity in attacks of multiple sclerosis
AID  - 10.1212/WNL.27.2.132
DP  - 1977 Feb 01
TA  - Neurology
PG  - 132--132
VI  - 27
IP  - 2
4099  - http://n.neurology.org/content/27/2/132.short
4100  - http://n.neurology.org/content/27/2/132.full
SO  - Neurology1977 Feb 01; 27
AB  - Although cell-mediated hypersensitivity to basic myelin protein has been demonstrated in multiple sclerosis with use of cell migration assays, results with the lymphoblastic transformation technique have been inconclusive. However, prospective studies relating results of lymphoblastic transformation to the clinical course of multiple sclerosis have not been reported. In the present study, both lymphoblastic transformation and migration inhibitory factor assays were used, and results related to the temporal course of multiple sclerosis. Results of the present investigation show that cell-mediated hypersensitivity to myelin basic A1 protein is most significant during exacerbations of multiple sclerosis. Responses obtained employing either the lymphoblastic transformation or migration inhibitory factor assay were equally significant. The results support the hypothesis that a factor suppressing deoxyribonucleic acid synthesis is present in multiple sclerosis and is inhibited by the use of steroids.