RT Journal Article
SR Electronic
T1 Elevated manganese levels associated with dementia and extrapyramidal signs
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 213
OP 213
DO 10.1212/WNL.27.3.213
VO 27
IS 3
A1 RICHARD G. BANT A
A1 WILLIAM R. MARKESBERY
YR 1977
UL http://n.neurology.org/content/27/3/213.abstract
AB In a patient with elevated manganese levels, dementia, and an extrapyramidal syndrome, brain biopsy showed numerous neuritic plaques and neurofibrillary tangles typical of Alzheimer's disease. Manganese was elevated beyond toxic levels in serum, hair, urine, feces, and brain. The possible relationship of elevated manganese levels, dementia, and the extrapyramidal syndrome warrants further studies of similar cases.