RT Journal Article
SR Electronic
T1 Salivary levels of anticonvulsants
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 409
OP 409
DO 10.1212/WNL.27.5.409
VO 27
IS 5
A1 JOHN J. McAULIFFE
A1 ALLAN L. SHERWIN
A1 ILO E. LEPPIK
A1 SHIRLEY A. FAYLE
A1 CHARLES E. PIPPENGER
YR 1977
UL http://n.neurology.org/content/27/5/409.abstract
AB Phenobarbital, phenytoin, carbamazepine, primidone, and ethosuximide were measured in saliva and plasma obtained simultaneously from 115 patients. A method to correct for the effect of salivary pH on phenobarbital concentration of saliva was developed. Salivary concentrations of these drugs were found to be equivalent to the plasma free drug and to correlate closely with the total plasma levels. Expressed as percent of total plasma drug, the salivary (S) and plasma free (P) concentrations were: phenytoin, S 11.1 ± 2.0 percent (mean ± SD), P 10.1 ± 2.4 percent (r = 0.97); carbamazepine, S 26.0 ± 2.4 percent, P 25.9 t 3.4 percent (r = 0.97); phenobarbital, S 43.1 ± 5.2 percent, P 40.8 ± 7.9 percent (r = 0.91); primidone, S 75.4 ± 24.9 percent, P 66.4 ± 8.8 percent (r = 0.76). Ethosuximide was not bound by plasma proteins, and its plasma and salivary levels were equal.