PT  - JOURNAL ARTICLE
AU  - RUGGERO G. FARIELLO
AU  - GEORGE A. BUBENIK
AU  - GREGORY M. BROWN
AU  - LEE J. GROTA
TI  - Epileptogenic action of intraventricularly injected antimelatonin antibody
AID  - 10.1212/WNL.27.6.567
DP  - 1977 Jun 01
TA  - Neurology
PG  - 567--567
VI  - 27
IP  - 6
4099  - http://n.neurology.org/content/27/6/567.short
4100  - http://n.neurology.org/content/27/6/567.full
SO  - Neurology1977 Jun 01; 27
AB  - In rats, intraventricularly injected antimelatonin antibody caused the appearance of transitory epileptiform abnormalities. Epileptic activity arose from and was limited to the cortical mantle of the hemisphere ipsilateral to the injection side. The occasional occurrence of lateralized seizures has also been observed. Control injection of saline, of the vehicle (rabbit serum), or of antibody saturated with melatonin induced flattening and desynchronization of the electroencephalogram but not epileptiform activity. Repeated antimelatonin injections caused reappearance of the same type of epileptic abnormalities that lasted slightly longer than the first time. Melatonin may play an inhibitory role in neuronal excitability.