RT Journal Article
SR Electronic
T1 Granulomatous angiitis of the brain
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 588
OP 588
DO 10.1212/WNL.27.6.588
VO 27
IS 6
A1 RODWAN K. RAJJOUB
A1 JAMES H. WOOD
A1 AYUB K. OMMAYA
YR 1977
UL http://n.neurology.org/content/27/6/588.abstract
AB A patient with clinical and radiographic findings initially suggesting a neoplasm was diagnosed as having Hodqkin disease. Computerized axial tomography demonstrated profound diffuse decreased density similar to that seen in cases of cerebral edema or leukomalacia. Cerebral angiography showed blood vessels with a beaded appearance. A diagnosis of granulomatous angiitis was made on the basis of brain biopsy specimens. Viral cultures were negative. Skin testing revealed poor responses to antigens. The patient improved dramatically following a combination of radiotherapy and steroid therapy. Resolution of the low-density abnormality seen on serial EMI scanning and resolution of the vasculitis demonstrated in the post-therapy brain biopsy specimen was dramatic. This is the first case of granulomatous angiitis of the brain diagnosed during life, and it points out the value of radiation and steroid therapy for relief of neurologic symptoms.