RT Journal Article
SR Electronic
T1 Computerized tomography in demyelinating disease of the young
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 838
OP 838
DO 10.1212/WNL.27.9.838
VO 27
IS 9
A1 WILLIAM C. ROBERTSON, Jr.
A1 MANUEL R. GOMEZ
A1 DAVID F. REESE
A1 HARUO OKAZAKI
YR 1977
UL http://n.neurology.org/content/27/9/838.abstract
AB We have used computerized tomography (CT) to look for evidence of cerebral demyelination in children with progressive neurologic disorders. Fourteen patients with a clinical diagnosis of a demyelinating disorder were examined by CT, and five had CT findings suggesting cerebral demyelination. In two patients with a so-called myelinoclastic demyelinating disease, CT showed asymmetric, circumscribed areas of diminished radiodensity, and in three patients with a leukodystrophy, scans showed diffuse symmetric areas of low density in the centrum ovale. Autopsy examination in one patient confirmed the diagnosis of sudanophilic leukodystrophy and substantiated the abnormalities suspected from CT.