PT  - JOURNAL ARTICLE
AU  - EDUARDO S. TOLOSA
AU  - GEORGE C. COTZIAS
AU  - PAUL S. PAPAVASILIOU
AU  - CHRISTINE B. LAZARUS
TI  - Antagonism by piperidine of levodopa effects in Parkinson disease
AID  - 10.1212/WNL.27.9.875
DP  - 1977 Sep 01
TA  - Neurology
PG  - 875--875
VI  - 27
IP  - 9
4099  - http://n.neurology.org/content/27/9/875.short
4100  - http://n.neurology.org/content/27/9/875.full
SO  - Neurology1977 Sep 01; 27
AB  - The nicotinic cholinergic amine piperidine diminished both the dyskinesia and the symptomatic control in some patients with Parkinson disease receiving levodopa. Since the piperidine configuration is contained in the molecules of apomorphine and N-propylnoraporphine, it might be responsible for the antagonism of these drugs to some effects of levodopa in Parkinson disease and for the palliation by apomorphine of some dopamine-mediated symptoms in other extrapyramidal disorders.