RT Journal Article
SR Electronic
T1 Antagonism by piperidine of levodopa effects in Parkinson disease
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 875
OP 875
DO 10.1212/WNL.27.9.875
VO 27
IS 9
A1 EDUARDO S. TOLOSA
A1 GEORGE C. COTZIAS
A1 PAUL S. PAPAVASILIOU
A1 CHRISTINE B. LAZARUS
YR 1977
UL http://n.neurology.org/content/27/9/875.abstract
AB The nicotinic cholinergic amine piperidine diminished both the dyskinesia and the symptomatic control in some patients with Parkinson disease receiving levodopa. Since the piperidine configuration is contained in the molecules of apomorphine and N-propylnoraporphine, it might be responsible for the antagonism of these drugs to some effects of levodopa in Parkinson disease and for the palliation by apomorphine of some dopamine-mediated symptoms in other extrapyramidal disorders.