PT  - JOURNAL ARTICLE
AU  - J. O. McNamara
AU  - S. Carwile
AU  - V. Hope
AU  - J. Luther
AU  - P. Miller
TI  - Effects of oral choline on human complex partial seizures
AID  - 10.1212/WNL.30.12.1334
DP  - 1980 Dec 01
TA  - Neurology
PG  - 1334--1334
VI  - 30
IP  - 12
4099  - http://n.neurology.org/content/30/12/1334.short
4100  - http://n.neurology.org/content/30/12/1334.full
SO  - Neurology1980 Dec 01; 30
AB  - We carried out an open study of the effects of large doses (12 to 16 gm per day) of oral choline on medically intractable human complex partial seizures (CPS). Marked increases of plasma choline concentration (75 to 300%) in three subjects were associated with (1) shorter duration of CPS, (2) less postseizure fatigue, and (3) slight increase of seizure frequency. Both the patients and their families considered the patients much improved. No differences in any of these evaluations were noted in a fourth subject who had less of an increase (21%) of plasma choline content. The results suggest that oral choline therapy may be a useful adjunct in the treatment of intractable CPS. A blinded prospective study will be necessary to assess this possibililty.