RT Journal Article
SR Electronic
T1 Effects of oral choline on human complex partial seizures
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1334
OP 1334
DO 10.1212/WNL.30.12.1334
VO 30
IS 12
A1 J. O. McNamara
A1 S. Carwile
A1 V. Hope
A1 J. Luther
A1 P. Miller
YR 1980
UL http://n.neurology.org/content/30/12/1334.abstract
AB We carried out an open study of the effects of large doses (12 to 16 gm per day) of oral choline on medically intractable human complex partial seizures (CPS). Marked increases of plasma choline concentration (75 to 300%) in three subjects were associated with (1) shorter duration of CPS, (2) less postseizure fatigue, and (3) slight increase of seizure frequency. Both the patients and their families considered the patients much improved. No differences in any of these evaluations were noted in a fourth subject who had less of an increase (21%) of plasma choline content. The results suggest that oral choline therapy may be a useful adjunct in the treatment of intractable CPS. A blinded prospective study will be necessary to assess this possibililty.