RT Journal Article
SR Electronic
T1 Serum magnesium is associated with the risk of dementia
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1716
OP 1722
DO 10.1212/WNL.0000000000004517
VO 89
IS 16
A1 Brenda C.T. Kieboom
A1 Silvan Licher
A1 Frank J. Wolters
A1 M. Kamran Ikram
A1 Ewout J. Hoorn
A1 Robert Zietse
A1 Bruno H. Stricker
A1 M. Arfan Ikram
YR 2017
UL http://n.neurology.org/content/89/16/1716.abstract
AB Objective: To determine if serum magnesium levels are associated with the risk of all-cause dementia and Alzheimer disease.Methods: Within the prospective population-based Rotterdam Study, we measured serum magnesium levels in 9,569 participants, free from dementia at baseline (1997–2008). Participants were subsequently followed up for incident dementia, determined according to the DSM-III-R criteria, until January 1, 2015. We used Cox proportional hazard regression models to associate quintiles of serum magnesium with incident all-cause dementia. We used the third quintile as a reference group and adjusted for age, sex, Rotterdam Study cohort, educational level, cardiovascular risk factors, kidney function, comorbidities, other electrolytes, and diuretic use.Results: Our study population had a mean age of 64.9 years and 56.6% were women. During a median follow-up of 7.8 years, 823 participants were diagnosed with all-cause dementia. Both low serum magnesium levels (≤0.79 mmol/L) and high serum magnesium levels (≥0.90 mmol/L) were associated with an increased risk of dementia (hazard ratio [HR] 1.32, 95% confidence interval [CI] 1.02–1.69, and HR 1.30, 95% CI 1.02–1.67, respectively).Conclusions: Both low and high serum magnesium levels are associated with an increased risk of all-cause dementia. Our results warrant replication in other population-based studies.AD=Alzheimer disease; CI=confidence interval; CV=coefficient of variation; DSM-III-R=Diagnostic and Statistical Manual of Mental Disorders, 3rd edition, revised; GMS=Geriatric Mental Schedule; HR=hazard ratio; MMSE=Mini-Mental State Examination; NINCDS-ADRDA=National Institute of Neurological and Communicative Disorders and Stroke–Alzheimer's Disease and Related Disorders Association