RT Journal Article SR Electronic T1 Retinal signs and 20-year cognitive decline in the Atherosclerosis Risk in Communities Study JF Neurology JO Neurology FD Lippincott Williams & Wilkins SP e1158 OP e1166 DO 10.1212/WNL.0000000000005205 VO 90 IS 13 A1 Deal, Jennifer A. A1 Sharrett, A. Richey A1 Rawlings, Andreea M. A1 Gottesman, Rebecca F. A1 Bandeen-Roche, Karen A1 Albert, Marilyn A1 Knopman, David A1 Selvin, Elizabeth A1 Wasserman, Bruce A. A1 Klein, Barbara A1 Klein, Ronald YR 2018 UL http://n.neurology.org/content/90/13/e1158.abstract AB Objective To test the hypothesis that retinal vascular signs are associated with greater cognitive decline over 20 years in 12,317 men and women 50 to 73 years of age at baseline.Methods A composite cognitive score was created with 3 neuropsychological tests measured at 3 time points (1990–1992 to 2011–2013). Retinal signs were measured with fundus photography (1993–1995). Differences in cognitive change by retinal signs status were estimated with linear mixed models. Cognitive scores were imputed for living participants with incomplete cognitive testing.Results In multivariable-adjusted analyses that controlled for attrition, loss of vascular integrity (retinopathy and its components) was associated with greater 20-year decline (difference in 20-year cognitive change for moderate/severe vs no retinopathy −0.53 SD, 95% confidence interval −0.74 to −0.33). Estimated differences were similar in participants with and without diabetes mellitus and in white and black participants.Conclusions Retinopathy was associated with accelerated rates of 20-year cognitive decline. These findings support the exploration of more sensitive measures in the eye such as optical coherence tomography angiography, which may provide surrogate indexes of microvascular lesions relevant to cognitive decline in older adults.ARIC=Atherosclerosis Risk in Communities; CHD=coronary heart disease; CI=confidence interval; CRAE=central retinal arteriolar equivalent; ETDRS=Early Treatment Diabetic Retinopathy Study; OR=odds ratio; 3MS=Modified Mini-Mental State Examination