PT  - JOURNAL ARTICLE
AU  - Sophie Lefèvre-Arbogast
AU  - David Gaudout
AU  - Julien Bensalem
AU  - Luc Letenneur
AU  - Jean-François Dartigues
AU  - Boris P. Hejblum
AU  - Catherine Féart
AU  - Cécile Delcourt
AU  - Cécilia Samieri
TI  - Pattern of polyphenol intake and the long-term risk of dementia in older persons
AID  - 10.1212/WNL.0000000000005607
DP  - 2018 May 29
TA  - Neurology
PG  - e1979--e1988
VI  - 90
IP  - 22
4099  - http://n.neurology.org/content/90/22/e1979.short
4100  - http://n.neurology.org/content/90/22/e1979.full
SO  - Neurology2018 May 29; 90
AB  - Objective To investigate the optimal combination of dietary polyphenols associated with the long-term risk of dementia in a large prospective French cohort of older persons, the Three-City (3C) Study.Methods We included 1,329 older adults without dementia from the 3C study with assessment of intake of 26 polyphenol subclasses who were followed up for 12 years for dementia. Using partial least squares for Cox models, we identified a pattern of polyphenol intake associated with dementia risk.Results The pattern combined several flavonoids (dihydroflavonols, anthocyanins, isoflavonoids, flavanones), stilbenes (including resveratrol), lignans, and other subclasses (hydroxybenzaldehydes, naphthoquinones, furanocoumarins). Compared with participants in the lower quintile of pattern score, those in the higher quintile had a 50% lower risk of dementia (95% confidence interval 20%–68%, p for trend <0.01) in multivariate models.Conclusions In this French cohort, a polyphenol pattern provided by a diet containing specific plant products (nuts, citrus, berries, leafy vegetables, soy, cereals, olive oil) accompanied by red wine and tea was associated with lower dementia risk.AD=Alzheimer disease; DSM-IV=Diagnostic and Statistical Manual of Mental Disorders, 4th edition; MIND=Mediterranean-Dietary Approach to Stop Hypertension Intervention for Neurodegenerative Delay; MMSE=Mini-Mental State Examination; PAQUID=Personnes Agées Quid; PLS-Cox=partial least squares regression for Cox model; SU.VI.MAX=Supplémentation en Vitamines et. Minéraux Antioxydants; 3C=Three-City