RT Journal Article
SR Electronic
T1 Pattern of polyphenol intake and the long-term risk of dementia in older persons
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP e1979
OP e1988
DO 10.1212/WNL.0000000000005607
VO 90
IS 22
A1 Sophie Lefèvre-Arbogast
A1 David Gaudout
A1 Julien Bensalem
A1 Luc Letenneur
A1 Jean-François Dartigues
A1 Boris P. Hejblum
A1 Catherine Féart
A1 Cécile Delcourt
A1 Cécilia Samieri
YR 2018
UL http://n.neurology.org/content/90/22/e1979.abstract
AB Objective To investigate the optimal combination of dietary polyphenols associated with the long-term risk of dementia in a large prospective French cohort of older persons, the Three-City (3C) Study.Methods We included 1,329 older adults without dementia from the 3C study with assessment of intake of 26 polyphenol subclasses who were followed up for 12 years for dementia. Using partial least squares for Cox models, we identified a pattern of polyphenol intake associated with dementia risk.Results The pattern combined several flavonoids (dihydroflavonols, anthocyanins, isoflavonoids, flavanones), stilbenes (including resveratrol), lignans, and other subclasses (hydroxybenzaldehydes, naphthoquinones, furanocoumarins). Compared with participants in the lower quintile of pattern score, those in the higher quintile had a 50% lower risk of dementia (95% confidence interval 20%–68%, p for trend <0.01) in multivariate models.Conclusions In this French cohort, a polyphenol pattern provided by a diet containing specific plant products (nuts, citrus, berries, leafy vegetables, soy, cereals, olive oil) accompanied by red wine and tea was associated with lower dementia risk.AD=Alzheimer disease; DSM-IV=Diagnostic and Statistical Manual of Mental Disorders, 4th edition; MIND=Mediterranean-Dietary Approach to Stop Hypertension Intervention for Neurodegenerative Delay; MMSE=Mini-Mental State Examination; PAQUID=Personnes Agées Quid; PLS-Cox=partial least squares regression for Cox model; SU.VI.MAX=Supplémentation en Vitamines et. Minéraux Antioxydants; 3C=Three-City