PT  - JOURNAL ARTICLE
AU  - Antel, Jack P.
AU  - Rosenkoetter, Maureen
AU  - Reder, Anthony
AU  - Oger, Joel J-F.
AU  - Arnason, Barry G.W.
TI  - Multiple sclerosis
AID  - 10.1212/WNL.34.9.1155
DP  - 1984 Sep 01
TA  - Neurology
PG  - 1155--1155
VI  - 34
IP  - 9
4099  - http://n.neurology.org/content/34/9/1155.short
4100  - http://n.neurology.org/content/34/9/1155.full
SO  - Neurology1984 Sep 01; 34
AB  - The proportion of MS patients whose pokeweed mitogen-stimulated mononuclear cells (MNCs) secreted >1,000 ng/ml IgG per 106 cells (ie, “high responders”) was increased compared with controls. The suppressor effect mediated by a constant number of T8+ cells from high responders, both MS and control, on IgG secretion by standard T helper (T4+) plus B-cell cultures was significantly lower than that for the same number of T8+ cells from “low responders.” The proportion of T8+ cells within MNCs from MS patients did not correlate with levels of IgG secretion. Our results indicate that high levels of IgG secretion by MNCs, an occurrence overrepresented in the MS population, is significantly influenced by functional properties of T suppressor cells.