RT Journal Article
SR Electronic
T1 Multiple sclerosis
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1155
OP 1155
DO 10.1212/WNL.34.9.1155
VO 34
IS 9
A1 Antel, Jack P.
A1 Rosenkoetter, Maureen
A1 Reder, Anthony
A1 Oger, Joel J-F.
A1 Arnason, Barry G.W.
YR 1984
UL http://n.neurology.org/content/34/9/1155.abstract
AB The proportion of MS patients whose pokeweed mitogen-stimulated mononuclear cells (MNCs) secreted >1,000 ng/ml IgG per 106 cells (ie, “high responders”) was increased compared with controls. The suppressor effect mediated by a constant number of T8+ cells from high responders, both MS and control, on IgG secretion by standard T helper (T4+) plus B-cell cultures was significantly lower than that for the same number of T8+ cells from “low responders.” The proportion of T8+ cells within MNCs from MS patients did not correlate with levels of IgG secretion. Our results indicate that high levels of IgG secretion by MNCs, an occurrence overrepresented in the MS population, is significantly influenced by functional properties of T suppressor cells.