PT  - JOURNAL ARTICLE
AU  - Fishman, Paul S.
AU  - Kelly, James P.
TI  - The fate of severed corticospinal axons
AID  - 10.1212/WNL.34.9.1161
DP  - 1984 Sep 01
TA  - Neurology
PG  - 1161--1161
VI  - 34
IP  - 9
4099  - http://n.neurology.org/content/34/9/1161.short
4100  - http://n.neurology.org/content/34/9/1161.full
SO  - Neurology1984 Sep 01; 34
AB  - The potential for regeneration of severed corticospinal axons was examined by labeling these axons with horseradish peroxidase following thoracic spinal cord transections in mice. Shortly after severance, the proximal ends of corticospinal axons formed terminal bulbs that persisted for weeks and were associated with axonal retraction. There were few signs of corticospinal axonal sprouting or elongation. By 2 months after injury, corticospinal axons near the transection site showed an increased number of probable labeled terminals in the adjacent gray matter. These new terminals may contribute to the persistence of many corticospinal axons near the injury site long after a spinal cord transection.