RT Journal Article
SR Electronic
T1 Antibody to acetylcholine receptor in myasthenia gravis
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1182
OP 1182
DO 10.1212/WNL.34.9.1182
VO 34
IS 9
A1 Fujii, Yoshitaka
A1 Monden, Yasumasa
A1 Nakahara, Kazuya
A1 Hashimoto, Jumpei
A1 Kawashima, Yasunaru
YR 1984
UL http://n.neurology.org/content/34/9/1182.abstract
AB In 13 of 17 myasthenic patients without thymoma and all 7 patients with thymoma, thymic lymphocytes produced antibody to acetylcholine receptor (AChR). Lymphocytes from the thymoma itself did not produce AChR antibody except in one patient. The rate of antibody production was higher in patients without thymoma than in patients with thymoma (32.5 and 3.9 fmol/106 cells/week, respectively). The rate of antibody production was related to the serum titer of AChR antibody (r = 0.7, p < 0.001). Enrichment of B cells using a nylon wool column increased the rate of antibody production by thymic lymphocytes 1.3- to 8.0-fold.