RT Journal Article
SR Electronic
T1 Low serum 24,25 dihydroxyvitamin D in Duchenne muscular dystrophy
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1192
OP 1192
DO 10.1212/WNL.34.9.1192
VO 34
IS 9
A1 Shapira, Yehuda A.
A1 Patz, David
A1 Menczel, Jacob
A1 Schwartz, Lydia
A1 Meyer, Shirley
A1 Frutkoff, Irving W.
A1 Kidroni, Gideon
YR 1984
UL http://n.neurology.org/content/34/9/1192.abstract
AB Levels of serum 24,25(OH)2D3 (0.69 ± 0.17 ng/ml) were lower in DMD patients than in age-matched controls (2.13 ± 0.15 ng/ml). Circulating levels of 1,25(OH)2D3 and 25(OH)D3 were within the accepted normal range. Bearing in mind the proposed pathophysiologic role of calcium in DMD and the influence of vitamin D metabolites on muscle ATP and protein synthesis, as well as on sarcoplasmic reticulum calcium transport and muscle mitochondrial calcium content, the above findings of low or deficient 24,25(OH)2D3 levels in DMD could be meaningful from the etiologic and therapeutic points of view.