PT  - JOURNAL ARTICLE
AU  - Walker, Francis O.
AU  - Young, Anne B.
AU  - Penney, John B.
AU  - Dovorini-Zis, Katerina
AU  - Shoulson, Ira
TI  - Benzodiazepine and GABA receptors in early Huntington's disease
AID  - 10.1212/WNL.34.9.1237
DP  - 1984 Sep 01
TA  - Neurology
PG  - 1237--1237
VI  - 34
IP  - 9
4099  - http://n.neurology.org/content/34/9/1237.short
4100  - http://n.neurology.org/content/34/9/1237.full
SO  - Neurology1984 Sep 01; 34
AB  - We compared autoradiographic measurements of GABA and benzodiazepine receptors in the brains of two early cases of Huntington's disease (HD), five controls, and four advanced cases of HD. These receptors increase in lateral globus pallidus and decrease in putamen early in the disease, before there is any extensive cell loss and atrophy. The cause of these receptor changes is unknown, but could imply dysfunction rather than death of striatal neurons.