RT Journal Article
SR Electronic
T1 Benzodiazepine and GABA receptors in early Huntington's disease
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1237
OP 1237
DO 10.1212/WNL.34.9.1237
VO 34
IS 9
A1 Walker, Francis O.
A1 Young, Anne B.
A1 Penney, John B.
A1 Dovorini-Zis, Katerina
A1 Shoulson, Ira
YR 1984
UL http://n.neurology.org/content/34/9/1237.abstract
AB We compared autoradiographic measurements of GABA and benzodiazepine receptors in the brains of two early cases of Huntington's disease (HD), five controls, and four advanced cases of HD. These receptors increase in lateral globus pallidus and decrease in putamen early in the disease, before there is any extensive cell loss and atrophy. The cause of these receptor changes is unknown, but could imply dysfunction rather than death of striatal neurons.