RT Journal Article
SR Electronic
T1 Cerebral blood flow changes in benign aging and cerebrovascular disease
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 855
OP 855
DO 10.1212/WNL.34.7.855
VO 34
IS 7
A1 Shaw, Terry G.
A1 Mortel, Karl F.
A1 Meyer, John Stirling
A1 Rogers, Robert L.
A1 Hardenberg, Jeffery
A1 Cutaia, Michael M.
YR 1984
UL http://n.neurology.org/content/34/7/855.abstract
AB Cross-sectional analysis of CBF values was carried out among 668 volunteers and patients. Subjects were subdivided according to age, gender, and degree of cerebrovascular disease, ranging from healthy volunteers with or without risk factors for stroke to patients with multi-infarct dementia. Four-year longitudinal analysis was also carried out on 230 individuals from the original sample, Decrements in CBF values were evidenced by both cross-sectional and longitudinal analysis in relation to advancing age, progressive cerebrovascular disease, and dementia. Regional, age-related CBF declines in healthy volunteers were heterogeneous, possibly related to changes in levels of functional activity within different brain regions.