RT Journal Article
SR Electronic
T1 Prevalence of Vascular Co-morbidities in patients with Multiple Sclerosis in a Racially Diverse and Low Socioeconomic Status Population (P4.2-059)
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP P4.2-059
VO 92
IS 15 Supplement
A1 Hellerslia, Van
A1 Gettings, Edward
A1 Weiner, Mark
A1 Zhao, Huaqing
YR 2019
UL http://n.neurology.org/content/92/15_Supplement/P4.2-059.abstract
AB Objective: To examine the prevalence of vascular co-morbidities in patients with multiple sclerosis (MS) compared to the general population in a racially diverse and low socioeconomic populationBackground: Despite the importance of co-morbidity, race and socioeconomic status on health outcomes, epidemiological studies on the prevalence and incidence of vascular co-morbidities in patients multiple sclerosis in cohorts with racial heterogeneity and low socioeconomic status are lacking.Design/Methods: Preliminary de-identified aggregate data was obtained utilizing TriNetX, a global federated health research network providing access to statistics on electronic medical records from almost 1 million patients in one inner city health care organization (HCO). The majority of patients receiving care from this HCO are racially diverse and have low socioeconomic status. A query was built to identify the number of patients in the general population with the following co-morbidities: diabetes mellitus, hypertension, and disorders of lipoprotein metabolism and other lipidemias. A similar query was performed but with the addition of an MS diagnosis. The odds ratio and 95% confidence interval were calculated using Medcalc® statistical software. If statistically significant differences were identified through this preliminary analysis then a multivariable logistic regression analysis would be completed using de-identified individual data.Results: Data queried on October 4, 2018 identified a total of 952,080 patients in our database with 1,720 patients with incident multiple sclerosis. In patients with MS compared to the general population, the odds ratio (95% confidence interval) were: hypertension, 2.40 (2.17–2.67; p<0.0001); disorders of lipoprotein metabolism 2.16 (1.93–2.42; p<0.0001); diabetes, 2.01 (1.75–2.31; p< 0.001). Multi-variate analysis data to be collected and shared at meeting.Conclusions: Preliminary univariate analysis suggest an increase in the prevalence of vascular co-morbidities in MS patients compared to the general population among an inner city low socioeconomic cohort.Disclosure: Dr. Hellerslia has nothing to disclose. Dr. Gettings has nothing to disclose. Dr. Weiner has nothing to disclose. Dr. Zhao has nothing to disclose.