RT Journal Article
SR Electronic
T1 Prediagnostic plasma branched-chain amino acids and the risk of amyotrophic lateral sclerosis
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP e2081
OP e2088
DO 10.1212/WNL.0000000000006669
VO 92
IS 18
A1 Bjornevik, Kjetil
A1 O'Reilly, Éilis J.
A1 Berry, James D.
A1 Clish, Clary B.
A1 Jeanfavre, Sarah
A1 Kato, Ikuko
A1 Kolonel, Laurence N.
A1 Le Marchand, Loic
A1 McCullough, Marjorie L.
A1 Paganoni, Sabrina
A1 Schwarzschild, Michael A.
A1 Talbott, Evelyn O.
A1 Wallace, Robert B.
A1 Zhang, Zhongli
A1 Manson, JoAnn E.
A1 Ascherio, Alberto
YR 2019
UL http://n.neurology.org/content/92/18/e2081.abstract
AB Objective To assess whether prediagnostic levels of plasma branched-chain amino acids (BCAAs) are associated with amyotrophic lateral sclerosis (ALS) risk.Methods We included participants from 5 large cohort studies—The Nurses' Health Study, the Health Professionals Follow-up Study, the Cancer Prevention Study II Nutrition, the Multiethnic Cohort Study, and the Women's Health Initiative—and identified 275 individuals who developed ALS during follow-up. Two controls were randomly selected for each case, matched on cohort, age, sex, fasting status, and time of blood draw. We measured metabolites using liquid chromatography–mass spectrometry and used conditional logistic regression to estimate rate ratios (RRs) and 95% confidence intervals (CIs) for the association of individual BCAAs with ALS risk.Results None of the 3 BCAAs was associated with a higher ALS risk. The risk estimates were similar for leucine (RR top vs bottom quartile: 0.87, 95% CI 0.57–1.33), isoleucine (RR top vs bottom quartile: 0.81, 95% CI 0.52–1.24), and valine (RR top vs bottom quartile: 0.80, 95% CI 0.52–1.23) in a multivariable analysis adjusted for body mass index, smoking, level of education, and physical activity. The estimates did not vary significantly by sex, fasting status, or time interval between blood draw and disease onset.Conclusion The results from this study do not support the hypothesis that BCAAs are risk factors for ALS.ALS=amyotrophic lateral sclerosis; BCAA=branched-chain amino acids; BMI=body mass index; CI=confidence interval; CPS-II Nutrition=Cancer Prevention Study II Nutrition Cohort; HPFS=Health Professionals Follow-up Study; ICD-9=International Classification of Diseases, Ninth Revision; MEC=Multiethnic Cohort Study; NHS=Nurses' Health Study; NMR=nuclear magnetic resonance; OR=odds ratio; PPV=positive predictive value; RR=rate ratio; WHI=Women's Health Initiative