RT Journal Article
SR Electronic
T1 Krabbe disease
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 111
OP 111
DO 10.1212/WNL.36.1.111
VO 36
IS 1
A1 Tallie Z. Baram
A1 Arnold M. Goldman
A1 Alan K. Percy
YR 1986
UL http://n.neurology.org/content/36/1/111.abstract
AB In three patients with Krabbe disease (galactosylceramide lipidosis), CT and MRI patterns progressed with the evolution of the disease. At first, discrete and symmetric dense areas on CT were found in deep gray matter of hemispheres and brainstem, and also in periventricular and capsular white matter. MRI showed decreased T1 values with normal or slightly decreased T2 values in those areas and large symmetric “plaque-like” lesions with high T1 and T2 values in white matter of the centrum semiovale. Later, both CT and MRI revealed diffuse reduction in gray matter and, more profoundly, in white matter mass. These findings may alert clinicians to the possibility of Krabbe disease in infants with progressive encephalopathy.