RT Journal Article
SR Electronic
T1 Intracerebral hemorrhage location and outcome among INTERACT2 participants
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1408
OP 1414
DO 10.1212/WNL.0000000000003771
VO 88
IS 15
A1 Delcourt, Candice
A1 Sato, Shoichiro
A1 Zhang, Shihong
A1 Sandset, Else Charlotte
A1 Zheng, Danni
A1 Chen, Xiaoying
A1 Hackett, Maree L.
A1 Arima, Hisatomi
A1 Hata, Jun
A1 Heeley, Emma
A1 Salman, Rustam Al-Shahi
A1 Robinson, Thompson
A1 Davies, Leo
A1 Lavados, Pablo M.
A1 Lindley, Richard I.
A1 Stapf, Christian
A1 Chalmers, John
A1 Anderson, Craig S.
A1 ,
YR 2017
UL http://n.neurology.org/content/88/15/1408.abstract
AB Objective: To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2).Methods: Associations between ICH sites and poor outcomes (death [6] or major disability [3–5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90 days were assessed in logistic regression models.Results: Of 2,066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (≤0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all health-related quality of life domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability, and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively).Conclusion: Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule.ClinicalTrials.gov registration: NCT00716079.BP=blood pressure; CI=confidence interval; EQ-5D=European Quality of Life Scale; HRQoL=health-related quality of life; ICH=intracerebral hemorrhage; IQR=interquartile range; IVH=intraventricular hemorrhage; INTERACT2=Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial; mRS=modified Rankin Scale; NIHSS=NIH Stroke Scale; OR=odds ratio