RT Journal Article
SR Electronic
T1 Unique white matter structural connectivity in early-stage drug-naive Parkinson disease
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP e774
OP e784
DO 10.1212/WNL.0000000000008867
VO 94
IS 8
A1 Mishra, Virendra R.
A1 Sreenivasan, Karthik R.
A1 Yang, Zhengshi
A1 Zhuang, Xiaowei
A1 Cordes, Dietmar
A1 Mari, Zoltan
A1 Litvan, Irene
A1 Fernandez, Hubert H.
A1 Eidelberg, David
A1 Ritter, Aaron
A1 Cummings, Jeffrey L.
A1 Walsh, Ryan R.
YR 2020
UL http://n.neurology.org/content/94/8/e774.abstract
AB Objective To investigate the topographic arrangement and strength of whole-brain white matter (WM) structural connectivity in patients with early-stage drug-naive Parkinson disease (PD).Methods We employed a model-free data-driven approach for computing whole-brain WM topologic arrangement and connectivity strength between brain regions by utilizing diffusion MRI of 70 participants with early-stage drug-naive PD and 41 healthy controls. Subsequently, we generated a novel group-specific WM anatomical network by minimizing variance in anatomical connectivity of each group. Global WM connectivity strength and network measures were computed on this group-specific WM anatomical network and were compared between the groups. We tested correlations of these network measures with clinical measures in PD to assess their pathophysiologic relevance.Results PD-relevant cortical and subcortical regions were identified in the novel PD-specific WM anatomical network. Impaired modular organization accompanied by a correlation of network measures with multiple clinical variables in early PD were revealed. Furthermore, disease duration was negatively correlated with global connectivity strength of the PD-specific WM anatomical network.Conclusion By minimizing variance in anatomical connectivity, this study found the presence of a novel WM structural connectome in early PD that correlated with clinical symptoms, despite the lack of a priori analytic assumptions. This included the novel finding of increased structural connectivity between known PD-relevant brain regions. The current study provides a framework for further investigation of WM structural changes underlying the clinical and pathologic heterogeneity of PD.AD=Alzheimer disease; DaT=dopamine uptake transporter; dMRI=diffusion MRI; FA=fractional anisotropy; FW=free-water; HC=healthy controls; Inf-Fron-Tri-Left=left frontal inferior triangularis; MDS-UPDRS-III=Movement Disorder Society–sponsored Unified Parkinson's Disease Rating Scale Part III; MNI=Montreal Neurological Institute; MoCA=Montreal Cognitive Assessment; NBS=network-based statistic; PALM=permutation analysis of linear models; PD=Parkinson disease; PPMI=Parkinson's Progression Markers Initiative; ROI=region of interest; SMA=supplementary motor area; WM=white matter