RT Journal Article
SR Electronic
T1 Granulomatosis-associated myositis
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP e910
OP e920
DO 10.1212/WNL.0000000000008863
VO 94
IS 9
A1 Dieudonné, Yannick
A1 Allenbach, Yves
A1 Benveniste, Olivier
A1 Leonard-Louis, Sarah
A1 Hervier, Baptiste
A1 Mariampillai, Kuberaka
A1 Nespola, Benoit
A1 Lannes, Béatrice
A1 Echaniz-Laguna, Andoni
A1 Wendling, Daniel
A1 Von Frenckell, Christian
A1 Poursac, Nicolas
A1 Mortier, Emmanuel
A1 Lavigne, Christian
A1 Hinschberger, Olivier
A1 Magnant, Julie
A1 Gottenberg, Jacques-Eric
A1 Geny, Bernard
A1 Sibilia, Jean
A1 Meyer, Alain
YR 2020
UL http://n.neurology.org/content/94/9/e910.abstract
AB Objective To refine the predictive significance of muscle granuloma in patients with myositis.Methods A group of 23 patients with myositis and granuloma on muscle biopsy (granuloma-myositis) from 8 French and Belgian centers was analyzed and compared with (1) a group of 23 patients with myositis without identified granuloma (control-myositis) randomly sampled in each center and (2) a group of 20 patients with sporadic inclusion body myositis (sIBM) without identified granuloma (control-sIBM).Results All but 2 patients with granuloma-myositis had extramuscular involvement, including signs common in sarcoidosis that were systematically absent in the control-myositis and the control-sIBM groups. Almost half of patients with granuloma-myositis matched the diagnostic criteria for sIBM. In these patients, other than the granuloma, the characteristics of the myopathy and its nonresponse to treatment were similar to the control-sIBM patients. Aside from 1 patient with myositis overlapping with systemic sclerosis, the remaining patients with granuloma-myositis did not match the criteria for a well-defined myositis subtype, suggesting pure sarcoidosis. Matching criteria for sIBM was the sole feature independently associated with nonresponse to myopathy treatment in patients with granuloma-myositis.Conclusion Patients with granuloma-myositis should be carefully screened for sIBM associated with sarcoidosis in order to best tailor their care.CK=creatine kinase; DM=dermatomyositis; ENMC=European Neuromuscular Centre; EULAR/ACR=European League Against Rheumatism/American College of Rheumatology; NAM=necrotizing autoimmune myopathy; OM=overlap myositis; PM=polymyositis; sIBM=sporadic inclusion body myositis