PT  - JOURNAL ARTICLE
AU  - Peroutka, Stephen J.
AU  - Kitamura, Kumiko
AU  - Lim, Mae
AU  - Steinman, Lawrence
TI  - Treatment of lethal pertussis vaccine reaction with histamine H<sub>1</sub> antagonists
AID  - 10.1212/WNL.37.6.1068
DP  - 1987 Jun 01
TA  - Neurology
PG  - 1068--1068
VI  - 37
IP  - 6
4099  - http://n.neurology.org/content/37/6/1068.short
4100  - http://n.neurology.org/content/37/6/1068.full
SO  - Neurology1987 Jun 01; 37
AB  - We studied mortality after pertussis immunization in the mouse. Without treatment, 73 of 92 animals (80%) died after injection of bovine serum albumin (BSA) on day +7 of pertussis immunization. After pretreatment with 3 mg of cyproheptadine, 2 mg mianserin, or 2 mg clorpheniramine, only 5 of 105 animals (5%) died after receiving BSA on day +7 (I) <0.001). Blockade of histamine H1 receptors may reduce mortality in pertussis immunization-induced encephalopathy in mice.