RT Journal Article
SR Electronic
T1 Treatment of lethal pertussis vaccine reaction with histamine H<sub>1</sub> antagonists
JF Neurology
JO Neurology
FD Lippincott Williams &amp; Wilkins
SP 1068
OP 1068
DO 10.1212/WNL.37.6.1068
VO 37
IS 6
A1 Peroutka, Stephen J.
A1 Kitamura, Kumiko
A1 Lim, Mae
A1 Steinman, Lawrence
YR 1987
UL http://n.neurology.org/content/37/6/1068.abstract
AB We studied mortality after pertussis immunization in the mouse. Without treatment, 73 of 92 animals (80%) died after injection of bovine serum albumin (BSA) on day +7 of pertussis immunization. After pretreatment with 3 mg of cyproheptadine, 2 mg mianserin, or 2 mg clorpheniramine, only 5 of 105 animals (5%) died after receiving BSA on day +7 (I) &lt;0.001). Blockade of histamine H1 receptors may reduce mortality in pertussis immunization-induced encephalopathy in mice.