RT Journal Article
SR Electronic
T1 Autonomic function in parkinsonian patients relates to duration of disease
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1173
OP 1173
DO 10.1212/WNL.37.7.1173
VO 37
IS 7
A1 Ørskov, L.
A1 Jakobsen, J.
A1 Dupont, E.
A1 de Fine Olivarius, B.
A1 Christensen, N. J.
YR 1987
UL http://n.neurology.org/content/37/7/1173.abstract
AB Autonomic functions were studied after withdrawal of all medication in parkinsonian out-patients with short and long duration of disease and in age-matched healthy control subjects. Vagal heart control and noradrenergic response to standing were impaired and related to duration of symptoms of idiopathic parkinsonism. Cholinergic function of pupil motility was unchanged. The cholinergic dysfunction of heart rate variation, therefore, could be due to a specific loss of dopaminergic neurons in the vagal motor nucleus.