RT Journal Article
SR Electronic
T1 Does long‐term aggravation of Parkinson's disease result from nondopaminergic lesions?
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1539
OP 1539
DO 10.1212/WNL.37.9.1539
VO 37
IS 9
A1 Bonnet, A.-M.
A1 Loria, Y.
A1 Saint-Hilaire, M.-H.
A1 Lhermitte, F.
A1 Agid, Y.
YR 1987
UL http://n.neurology.org/content/37/9/1539.abstract
AB The motor score with and without levodopa was estimated in 193 parkinsonian patients with variable length of evolution. The effect of levodopa on akinesia, rigidity, and tremor remained quite stable during the course of the disease. In contrast, the aggravation of gait disorder, postural instability, and dysarthria was more severe, with decreased percentage of improvement on levodopa in patients with longer evolution. It is suggested that aggravation of Parkinson's disease mainly results from increasing severity of cerebral nondopaminergic lesions.