RT Journal Article
SR Electronic
T1 Clinical significance of antibodies against peripheral nerve tissue in inflammatory polyneuropathy
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP 1798
OP 1798
DO 10.1212/WNL.37.11.1798
VO 37
IS 11
A1 van Doorn, Pieter A.
A1 Brand, Anneke
A1 Vermeulen, Marinus
YR 1987
UL http://n.neurology.org/content/37/11/1798.abstract
AB With the use of a mixed hemagglutination test (MHT), circulating antibodies against human peripheral nerve tissue (PNT) were found in 22 of 38 patients with Guillain-Barré syndrome (GBS) or chronic relapsing demyelinating inflammatory polyneuropathy (CR-DIP). The antibodies were found in only 1 of 34 patients with polyneuropathy of other origin, and in 3 of 32 patients without polyneuropathy. The presence of antibodies was related to response to intravenous gamma globulin treatment in CR-DIP patients. Antibodies against PNT may be pathogenic.