RT Journal Article SR Electronic T1 Aerobic exercise improves cognition and cerebrovascular regulation in older adults JF Neurology JO Neurology FD Lippincott Williams & Wilkins SP e2245 OP e2257 DO 10.1212/WNL.0000000000009478 VO 94 IS 21 A1 Guadagni, Veronica A1 Drogos, Lauren L. A1 Tyndall, Amanda V. A1 Davenport, Margie H. A1 Anderson, Todd J. A1 Eskes, Gail A. A1 Longman, R. Stewart A1 Hill, Michael D. A1 Hogan, David B. A1 Poulin, Marc J. YR 2020 UL http://n.neurology.org/content/94/21/e2245.abstract AB Objective To test the hypothesis that aerobic exercise is associated with improvements in cognition and cerebrovascular regulation, we enrolled 206 healthy low-active middle-aged and older adults (mean ± SD age 65.9 ± 6.4 years) in a supervised 6-month aerobic exercise intervention and assessed them before and after the intervention.Methods The study is a quasi-experimental single group pre/postintervention study. Neuropsychological tests were used to assess cognition before and after the intervention. Transcranial Doppler ultrasound was used to measure cerebral blood flow velocity. Cerebrovascular regulation was assessed at rest, during euoxic hypercapnia, and in response to submaximal exercise. Multiple linear regression was used to examine the association between changes in cognition and changes in cerebrovascular function.Results The intervention was associated with improvements in some cognitive domains, cardiorespiratory fitness, and cerebrovascular regulation. Changes in executive functions were negatively associated with changes in cerebrovascular resistance index (CVRi) during submaximal exercise (β = −0.205, p = 0.013), while fluency improvements were positively associated with changes in CVRi during hypercapnia (β = 0.106, p = 0.03).Conclusion The 6-month aerobic exercise intervention was associated with improvements in some cognitive domains and cerebrovascular regulation. Secondary analyses showed a novel association between changes in cognition and changes in cerebrovascular regulation during euoxic hypercapnia and in response to submaximal exercise.BIM=Brain in Motion; CBF=cerebral blood flow; CVCi=cerebrovascular conductance index; CVRi=cerebrovascular resistance index; MCA=middle cerebral artery; MAP=mean arterial pressure; MoCA=Montreal Cognitive Assessment; PCA=principal component analysis; TCD=transcranial Doppler