RT Journal Article
SR Electronic
T1 Aerobic exercise improves cognition and cerebrovascular regulation in older adults
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP e2245
OP e2257
DO 10.1212/WNL.0000000000009478
VO 94
IS 21
A1 Guadagni, Veronica
A1 Drogos, Lauren L.
A1 Tyndall, Amanda V.
A1 Davenport, Margie H.
A1 Anderson, Todd J.
A1 Eskes, Gail A.
A1 Longman, R. Stewart
A1 Hill, Michael D.
A1 Hogan, David B.
A1 Poulin, Marc J.
YR 2020
UL http://n.neurology.org/content/94/21/e2245.abstract
AB Objective To test the hypothesis that aerobic exercise is associated with improvements in cognition and cerebrovascular regulation, we enrolled 206 healthy low-active middle-aged and older adults (mean ± SD age 65.9 ± 6.4 years) in a supervised 6-month aerobic exercise intervention and assessed them before and after the intervention.Methods The study is a quasi-experimental single group pre/postintervention study. Neuropsychological tests were used to assess cognition before and after the intervention. Transcranial Doppler ultrasound was used to measure cerebral blood flow velocity. Cerebrovascular regulation was assessed at rest, during euoxic hypercapnia, and in response to submaximal exercise. Multiple linear regression was used to examine the association between changes in cognition and changes in cerebrovascular function.Results The intervention was associated with improvements in some cognitive domains, cardiorespiratory fitness, and cerebrovascular regulation. Changes in executive functions were negatively associated with changes in cerebrovascular resistance index (CVRi) during submaximal exercise (β = −0.205, p = 0.013), while fluency improvements were positively associated with changes in CVRi during hypercapnia (β = 0.106, p = 0.03).Conclusion The 6-month aerobic exercise intervention was associated with improvements in some cognitive domains and cerebrovascular regulation. Secondary analyses showed a novel association between changes in cognition and changes in cerebrovascular regulation during euoxic hypercapnia and in response to submaximal exercise.BIM=Brain in Motion; CBF=cerebral blood flow; CVCi=cerebrovascular conductance index; CVRi=cerebrovascular resistance index; MCA=middle cerebral artery; MAP=mean arterial pressure; MoCA=Montreal Cognitive Assessment; PCA=principal component analysis; TCD=transcranial Doppler