RT Journal Article
SR Electronic
T1 Endovascular treatment in older adults with acute ischemic stroke in the MR CLEAN Registry
JF Neurology
JO Neurology
FD Lippincott Williams & Wilkins
SP e131
OP e139
DO 10.1212/WNL.0000000000009764
VO 95
IS 2
A1 Adrien E. Groot
A1 Kilian M. Treurniet
A1 Ivo G.H. Jansen
A1 Hester F. Lingsma
A1 Wouter Hinsenveld
A1 Rob A. van de Graaf
A1 Bob Roozenbeek
A1 Hanna C. Willems
A1 Wouter J. Schonewille
A1 Henk A. Marquering
A1 René van den Berg
A1 Diederik W.J. Dippel
A1 Charles B.L.M. Majoie
A1 Yvo B.W.E.M. Roos
A1 Jonathan M. Coutinho
A1 ,
YR 2020
UL http://n.neurology.org/content/95/2/e131.abstract
AB Objective To explore clinical outcomes in older adults with acute ischemic stroke treated with endovascular thrombectomy (EVT).Methods We included consecutive patients (2014–2016) with an anterior circulation occlusion undergoing EVT from the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN) Registry. We assessed the effect of age (dichotomized at ≥80 years and as continuous variable) on the modified Rankin Scale (mRS) score at 90 days, symptomatic intracranial hemorrhage (sICH), and reperfusion rate. The association between age and mRS was assessed with multivariable ordinal logistic regression, and a multiplicative interaction term was added to the model to assess modification of reperfusion by age on outcome.Results Of the 1,526 patients, 380 (25%) were ≥80 years of age (referred to here as older adults). Older adults had a worse functional outcome than younger patients (adjusted common odds ratio [acOR] for an mRS score shift toward better outcome 0.31, 95% confidence interval [CI] 0.24–0.39). Mortality was also higher in older adults (51% vs 22%, adjusted odds ratio 3.12, 95% CI 2.33–4.19). There were no differences in proportion of patients with mRS scores of 4 to 5, sICH, or reperfusion rates. Successful reperfusion was more strongly associated with a shift toward good functional outcome in older adults than in younger patients (acOR 3.22, 95% CI 2.04–5.10 vs 2.00, 95% CI 1.56–2.57, pinteraction = 0.026).Conclusion Older age is associated with an increased absolute risk of poor clinical outcome, while the relative benefit of successful reperfusion seems to be higher in these patients. These results should be taken into consideration in the selection of older adults for EVT.acOR=adjusted common OR; AIS=acute ischemic stroke; CI=confidence interval; DSA=digital subtraction angiography; eTICI=extended Thrombolysis in Cerebral Infarction; EVT=endovascular treatment; HERMES=Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke; IQR=interquartile range; MR CLEAN=Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands; mRS=modified Rankin Scale; NIHSS=NIH Stroke Scale; OR=odds ratio; sICH=symptomatic intracranial hemorrhage