PT  - JOURNAL ARTICLE
AU  - Rydén, Isabelle
AU  - Carstam, Louise
AU  - Gulati, Sasha
AU  - Smits, Anja
AU  - Sunnerhagen, Katharina S.
AU  - Hellström, Per
AU  - Henriksson, Roger
AU  - Bartek, Jiri
AU  - Salvesen, Øyvind
AU  - Jakola, Asgeir Store
TI  - Return to work following diagnosis of low-grade glioma
AID  - 10.1212/WNL.0000000000009982
DP  - 2020 Aug 18
TA  - Neurology
PG  - e856--e866
VI  - 95
IP  - 7
4099  - http://n.neurology.org/content/95/7/e856.short
4100  - http://n.neurology.org/content/95/7/e856.full
SO  - Neurology2020 Aug 18; 95
AB  - Objective Return-to-work (RTW) following diagnosis of infiltrative low-grade gliomas is unknown.Methods Swedish patients with histopathologic verified WHO grade II diffuse glioma diagnosed between 2005 and 2015 were included. Data were acquired from several Swedish registries. A total of 381 patients aged 18–60 were eligible. A matched control population (n = 1,900) was acquired. Individual data on sick leave, compensations, comorbidity, and treatments assigned were assessed. Predictors were explored using multivariable logistic regression.Results One year before surgery/index date, 88% of cases were working, compared to 91% of controls. The proportion of controls working remained constant, while patients had a rapid increase in sick leave approximately 6 months prior to surgery. After 1 and 2 years, respectively, 52% and 63% of the patients were working. Predictors for no RTW after 1 year were previous sick leave (odds ratio [OR] 0.92, 95% confidence interval [CI] 0.88–0.96, p < 0.001), older age (OR 0.96, 95% CI 0.94–0.99, p = 0.005), and lower functional level (OR 0.64 95% CI, 0.45–0.91 p = 0.01). Patients receiving adjuvant treatment were less likely to RTW within the first year. At 2 years, biopsy (as opposed to resection), female sex, and comorbidity were also unfavorable, while age and adjuvant treatment were no longer significant.Conclusions Approximately half of patients RTW within the first year. Lower functional status, previous sick leave, older age, and adjuvant treatment were risk factors for no RTW at 1 year after surgery. Female sex, comorbidity, and biopsy only were also unfavorable for RTW at 2 years.CI=confidence interval; ICD-10=International Classification of Diseases–10; LGG=low-grade glioma; NBHW=National Board of Health and Welfare; NPR=National Patient Registry; OR=odds ratio; RTW=return to work; SBTR=Swedish Brain Tumor Registry; SIA=Social Insurance Agency